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:: Editorial Board
:: About Iranian Journal of Endocrinology and Metabolism
:: Volume 25, Issue 5 (12-2023) ::
2023, 25(5): 407-415 Back to browse issues page
The Association of Prolactin Levels with Risk of Cardiovascular Diseases in Women: A Population-based Study
M Saei Ghare Naz , M Mousavi , Sh Amirshekari , F Azizi , F Ramezani Tehrani
Reproductive Endocrinology Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran. , fah.tehrani@gmail.com
Abstract:   (488 Views)
Introduction: Cardiovascular diseases are common health problems in women. Evidence shows that serum prolactin levels can be related to the development of cardiovascular diseases. This study aimed to determine the association between prolactin levels and cardiovascular diseases in women. Materials and Methods: In this population-based study, eligible women were chosen from the participants of the Tehran Lipid and Glucose Study. Cox model was used to evaluate the relationship between prolactin levels and the risk of cardiovascular diseases. Results: A total of 1279 women participated in this study. There was no significant difference in the prolactin levels between the two groups with and without cardiovascular diseases (p=0.98). Age (affected group: 36.97±7.24 years Vs. non-affected group: 31.68±7.26 years; p<0.001) and body mass index (BMI) (affected group: 28.07±4.52 kg/m2 Vs. non-affected group: 26.01±4.46 kg/m2; p<0.001) was significantly higher in the affected group than the non-affected group. Prolactin was not associated with an increased risk of cardiovascular diseases in the whole population and in the menopausal and non-menopausal groups. There was no association in unadjusted model. However, in the adjusted model, the risk of cardiovascular diseases increased by 7% and 12% for each unit of increase in age and BMI, respectively. Moreover, in postmenopausal women, the risk increased by 10 and 11% for each unit of increase in age and BMI, respectively. Also, the number of births increased the risk of cardiovascular diseases by 25% in the whole population and by 79% in women of reproductive age. Conclusion: The results of this study did not show a statistically significant association between the risk of cardiovascular diseases and the serum prolactin levels in women.
Keywords: Prolactin, Cardiovascular diseases, Women
Full-Text [PDF 1031 kb]   (405 Downloads)    
Type of Study: Original | Subject: Endocrinology
Received: 2024/05/27 | Accepted: 2024/08/12 | Published: 2023/12/31
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Saei Ghare Naz M, Mousavi M, Amirshekari S, Azizi F, Ramezani Tehrani F. The Association of Prolactin Levels with Risk of Cardiovascular Diseases in Women: A Population-based Study. Iranian Journal of Endocrinology and Metabolism 2023; 25 (5) :407-415
URL: http://ijem.sbmu.ac.ir/article-1-3173-en.html


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Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
Volume 25, Issue 5 (12-2023) Back to browse issues page
مجله ی غدد درون‌ریز و متابولیسم ایران، دو ماهنامه  پژوهشی مرکز تحقیقات غدد درون‌ریز و متابولیسم، Iranian Journal of Endocrinology and Metabolism
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