[Home ] [Archive]   [ فارسی ]  
:: Main :: About :: Current Issue :: Archive :: Search :: Contact ::
Main Menu
Home::
Journal Information::
Articles archive::
For Authors::
For Reviewers::
Subscription::
Contact us::
Site Facilities::
::
Search in website

Advanced Search
Receive site information
Enter your Email in the following box to receive the site news and information.
Last site contents
:: Editorial Board
:: About Iranian Journal of Endocrinology and Metabolism
:: Volume 24, Issue 4 (11-2022) ::
2022, 24(4): 235-240 Back to browse issues page
The Effect of Dried Lemon Peel on Chronic Immobilization-Induced Liver Damage in Male Wistar Rats
R Amini , M Asle-Rousta
Department of Physiology, Zanjan Branch, Islamic Azad University, Zanjan, I.R. Iran. , mrousta58@gmail.com
Abstract:   (1135 Views)
Introduction: Previous research has demonstrated that chronic immobilization can induce oxidative stress and result in liver damage. Dried lemons (Citrus aurantifolia) possess antioxidant, anti-inflammatory, and anti-apoptotic properties, as well as neuroprotective and cardioprotective effects. The objective of the present study is to examine the impact of hydroethanolic extract from dried lemon peel on liver damage caused by chronic immobilization in male Wistar rats. Materials and Methods: In this experimental study, 20 male Wistar rats were divided into four groups: control, dried lemon peel, chronic immobilization, and chronic immobilization-dried lemon peel. The chronic immobilization groups were subjected to restraint stress for 6 hours daily, continuously for 21 days. The dried lemon peel groups received a hydroethanolic extract of dried lemon peel (at a dose of 400 mg/kg body weight) by gavage. At the end of the study period, the levels of liver enzyme activity and liver malondialdehyde were measured. Results: The level of malondialdehyde in the liver of rats in the chronic immobilization group (0.532±0.045) was significantly higher compared to the control group (0.349±0.02). Moreover, the serum activity of alanine aminotransferase (51.61±4.58), aspartate aminotransferase (123.07±8.12), and alkaline phosphatase (310.62±13.96) enzymes in immobilized rats showed a significant increase compared to the control group (29.77±2.98, 73.10±7.03, and 209.53±7.00, respectively), indicating infiltration of inflammatory cells into the liver parenchyma. On the other hand, the chronic immobilization-dried lemon peel group exhibited a significant decrease in the level of malondialdehyde (0.407±0.004) and the activity of liver enzymes (alanine aminotransferase 35.73±2.29, aspartate aminotransferase 82.04±5.76, and alkaline phosphatase 231.0±15.91) compared to the chronic immobilization group. Conclusion: It is concluded that dried lemon peel probably acts as a hepatoprotective agent by inhibiting oxidative stress and protecting the liver from damage caused by chronic immobilization.
 
Keywords: Dried lemon (Citrus aurantifolia), Malondialdehyde, Liver enzymes, Chronic immobilization
Full-Text [PDF 1078 kb]   (186 Downloads)    
Type of Study: Original | Subject: Physiology
Received: 2022/10/31 | Accepted: 2022/12/25 | Published: 2022/11/1
Add your comments about this article
Your username or Email:

CAPTCHA


XML   Persian Abstract   Print


Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Amini R, Asle-Rousta M. The Effect of Dried Lemon Peel on Chronic Immobilization-Induced Liver Damage in Male Wistar Rats. Iranian Journal of Endocrinology and Metabolism 2022; 24 (4) :235-240
URL: http://ijem.sbmu.ac.ir/article-1-3029-en.html


Rights and permissions
Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
Volume 24, Issue 4 (11-2022) Back to browse issues page
مجله ی غدد درون‌ریز و متابولیسم ایران، دو ماهنامه  پژوهشی مرکز تحقیقات غدد درون‌ریز و متابولیسم، Iranian Journal of Endocrinology and Metabolism
Persian site map - English site map - Created in 0.06 seconds with 38 queries by YEKTAWEB 4642