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:: Volume 21, Issue 1 (7-2019) ::
2019, 21(1): 27-36 Back to browse issues page
The Effect of Maternal High-Fat Feeding on Energy Homeostasis in Stressed Adult Male Rat Offspring
Roxana Karbaschi Dr , Homeira Zardooz Dr
Shahid Beheshti University of Medical Sciences , homeira_zardooz@yahoo.com
Abstract:   (520 Views)
Introduction: In the present study the effect of chronic maternal high-fat diet consumption on energy homeostasis and glucose metabolism in response to chronic stress was investigated in adult male rats. Materials and Methods: Female rats were divided into two groups of normal and high fat diets. Each group received their diet from 3 weeks before pregnancy until the end of lactation. At 8 weeks of age, male offspring were divided into control and stress groups, the stress group receiving variable stress for 2 weeks. At the end of 10 weeks, plasma concentrations of glucose, insulin, corticosterone and leptin were measured and intra-abdominal fat was weighed in all male offspring. The body weight, food and calorie intake of the rats were also measured. Results: Maternal high-fat diet alone reduced intra-abdominal fat weight, plasma concentrations of corticosterone and leptin, body weight, food and calorie intake, although at had no effect on fasting plasma glucose and insulin concentrations, or on HOMA-IR index. In response to stress, the maternal high-fat diet reduced corticosterone and leptin plasma concentrations, body weight, food and calorie intake compared to the control group; whereas did not significantly change the intra-abdominal fat weight, plasma glucose and insulin levels as well as HOMA-IR index. Conclusion: From the results of the present study it seems we can conclude that maternal HFD feeding, in a critical developmental period (perinatal), by altering responsiveness of hypothalamic-pituitary-adrenal axis and/or central leptin sensitivity, exacerbates impaired energy homeostasis in stressed adult offspring.
Keywords: Maternal high-fat diet, Energy homeostasis, Stress, Offspring
Full-Text [PDF 1368 kb]   (174 Downloads)    
Type of Study: Original | Subject: Endocrinology
Received: 2019/02/5 | Accepted: 2019/04/30
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Karbaschi R, Zardooz H. The Effect of Maternal High-Fat Feeding on Energy Homeostasis in Stressed Adult Male Rat Offspring. Iranian Journal of Endocrinology and Metabolism. 2019; 21 (1) :27-36
URL: http://ijem.sbmu.ac.ir/article-1-2544-en.html


Volume 21, Issue 1 (7-2019) Back to browse issues page
مجله ی غدد درون‌ریز و متابولیسم ایران، دو ماهنامه  پژوهشی مرکز تحقیقات غدد درون‌ریز و متابولیسم، Iranian Journal of Endocrinology and Metabolism
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