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:: Editorial Board
:: About Iranian Journal of Endocrinology and Metabolism
:: Volume 20, Issue 5 (2-2019) ::
2019, 20(5): 246-252 Back to browse issues page
Effects of Eight Weeks of Aerobic Training on Expression Levels of the HMGB1-RAGE/TLR4-NF-kB Proinflammatory Pathway in Cardiac Tissue of Male Rats with Hyperglycemia
Hamid Taghibeigi Hoseinabadi , Fahimeh Esfarjani , Mohammad Marandi , Hadi Karami
University of Isfahan , f.esfarjani@spr.ui.ac.ir
Abstract:   (5278 Views)
Introduction: Inflammation plays a critical role in the pathogenesis of diabetic cardiomyopathy. The expression of HMGB1, a proinflammatory cytokine, and its downstream signaling pathway is upregulated in diabetes. The aim of this study was to investigate the effect of 8 weeks aerobic training on the expression levels of the HMGB1-RAGE/TLR4-NF-kB pathway in cardiac tissue of male rats with hyperglycemia. Materials and Methods: Thirty-six male Wistar rats (mean weight, 231±25g) were randomly divided into three groups (n=12 each): Healthy control, control hyperglycemia and trained hyperglycemia. Hyperglycemia was induced by intraperitoneal injection of strept­ozotocin  and nicotinamide. Forty-eight hours after completion of the training program (eight weeks aerobic training), cardiac tissue was removed under sterile conditions. Gene expression of HMGB1, RAGE, TLR4 and NF-kB were investigated, using Real-time PCR. For data analysis, one-way ANOVA and post-hoc Tukey’s test were used, with P<0.05 considered statistically significant. Results: Gene expression levels of HMGB1, RAGE, TLR4 and NF-kB were significantly (P=0.001) increased in the cardiac tissue of the hyperglycemic control group, compared with healthy controls. Eight weeks of aerobic training decreased the expression levels of the studied genes (P=0.001). Conclusion: It seems that aerobic training can prevent the negative effects of hyperglycemia via by attenuating gene expression levels of HMGB1, RAGE, TLR4 and NF-kB in the cardiac tissue of rats with hyperglycemia, and could hence be an important mechanism for cardiac function and preventing diabetic cardiomyopathy.
 
Keywords: Aerobic Training, HMGB1, RAGE, TLR4 and NF-kB, Diabetic Cardiomyopathy, Hyperglycemia
Full-Text [PDF 481 kb]   (1760 Downloads)    
Type of Study: Original | Subject: Exercise
Received: 2018/10/6 | Accepted: 2019/01/8 | Published: 2019/02/15
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Taghibeigi Hoseinabadi H, Esfarjani F, Marandi M, Karami H. Effects of Eight Weeks of Aerobic Training on Expression Levels of the HMGB1-RAGE/TLR4-NF-kB Proinflammatory Pathway in Cardiac Tissue of Male Rats with Hyperglycemia. Iranian Journal of Endocrinology and Metabolism 2019; 20 (5) :246-252
URL: http://ijem.sbmu.ac.ir/article-1-2477-en.html


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Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
Volume 20, Issue 5 (2-2019) Back to browse issues page
مجله ی غدد درون‌ریز و متابولیسم ایران، دو ماهنامه  پژوهشی مرکز تحقیقات غدد درون‌ریز و متابولیسم، Iranian Journal of Endocrinology and Metabolism
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