[Home ] [Archive]   [ فارسی ]  
:: Main :: About :: Current Issue :: Archive :: Search :: Contact ::
:: Volume 20, Issue 5 (2-2019) ::
2019, 20(5): 253-262 Back to browse issues page
Effects of Long-Term, High Doses of Nitrate Administration on Adiposity Index in Female Rats
Sajad Jeddi Dr , Fatemeh Bakhtiarzadeh , Sevda Gheibi Dr , Asghar Ghasemi Dr
Endocrine Physiology Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran. , Ghasemi@endocrine.ac.ir
Abstract:   (628 Views)
Introduction: Despite higher prevalence of obesity in women, the anti-obesity effects of nitrate have mostly been studied in male animals, using low doses of nitrate for short durations. This study aims at determining effects of long-term (6 months), administration of high doses of nitrate on the obesity indices of normal adult female rats. Materials and Methods: Female Wistar rats were divided into 3 groups (n=10/group): Control group received tap water and the two treatment groups received water containing 250 and 500 mg/L sodium nitrate for 6 months. Body weight, food intake, and water consumption were measured weekly. Naso-anal length, body mass index (BMI), Lee index, as well as abdominal and thoracic circumferences were determined every two months. Weights of white adipose tissue (WAT) and brown adipose tissue (BAT) were measured at the end of study and adiposity index was calculated. Results: Administration of nitrate had no effect on food intake but significantly (p<0.001) increased water consumption in female rats. Compared to the control group, there was no significant difference in body weight and nasal-to-anal length in the nitrate-treated rats. At the end of study, compared to controls, in nitrate-treated rats, BMI (23%), Lee index (7%), adiposity index (36%), weight of WAT as well as abdominal (5%) and thoracic (6%) circumferences were significantly lower. Weight of BAT was also significantly higher in the interscapular region, i.e 0.23±0.02, 0.39±0.03 and 0.32±0.02 gram in the control and nitrate groups (250 and 500 mg/L), respectively. and in the axillary region 0.24±0.03,  0.33±0.02 and 0.30±0.03 gram in the control and nitrate groups (250 and 500 mg/L), respectively. Conclusion: Nitrate administration prevents increase in adiposity in normal adult female rats, beneficial effects which may be associated with increased browning of WAT.
Keywords: Obesity, Nitrate, Nitric oxide, Adiposity index
Full-Text [PDF 564 kb]   (182 Downloads)    
Type of Study: Original | Subject: Physiology
Received: 2018/09/12 | Accepted: 2018/11/12
Add your comments about this article
Your username or Email:

CAPTCHA code


XML   Persian Abstract   Print


Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

jeddi S, Bakhtiarzadeh F, Gheibi S, Ghasemi A. Effects of Long-Term, High Doses of Nitrate Administration on Adiposity Index in Female Rats. Iranian Journal of Endocrinology and Metabolism. 2019; 20 (5) :253-262
URL: http://ijem.sbmu.ac.ir/article-1-2466-en.html


Volume 20, Issue 5 (2-2019) Back to browse issues page
مجله ی غدد درون‌ریز و متابولیسم ایران، دو ماهنامه  پژوهشی مرکز تحقیقات غدد درون‌ریز و متابولیسم، Iranian Journal of Endocrinology and Metabolism
Persian site map - English site map - Created in 0.06 seconds with 33 queries by YEKTAWEB 3858