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:: Volume 19, Issue 5 (1-2018) ::
2018, 19(5): 357-369 Back to browse issues page
The Consequences of Prenatal Excess Androgen Exposure in Anatomy of the Reproductive System and Physiology
Marz Salehi Jahromi Dr., Azita Zadeh-Vakili Dr., Fahimeh Ramezani Tehrani Dr.
Professor Shahid Beheshti University of Medical Sciences , ramezani@endocrine.ac.ir
Abstract:   (633 Views)

Introduction: The effects of environmental exposure during critical periods of gestational life on fetal growth and development have been confirmed by a large number of studies on human and animal models. Sex hormons are among the most influential environmental factor which affect on growth and development of different organs of fetus. Among them, androgens are the most important ones because they have various sources of production and secretion. Result previous studies that exposure to androgens during pregnancy may act as a teratogenic agent and cause defects, deministrated in offspring's endocrine and neural system developments. Considering the importance of this critical period for the development of some abnormal features in adulthood, basic research and clinical prevention efforts need to be run at this stage. This review article presents evidence on the effect of excessive androgens during fetal life on embryo development and evolution, which can lead to the development of certain phenotypes / diseases in adulthood.

Keywords: Prenatal exposure, Androgen excess, Fetal development
Full-Text [PDF 562 kb]   (109 Downloads)    
Type of Study: Review | Subject: Gynecology
Received: 2017/06/24 | Accepted: 2017/09/17 | Published: 2018/01/23
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Salehi Jahromi M, Zadeh-Vakili A, Ramezani Tehrani F. The Consequences of Prenatal Excess Androgen Exposure in Anatomy of the Reproductive System and Physiology. Iranian Journal of Endocrinology and Metabolism. 2018; 19 (5) :357-369
URL: http://ijem.sbmu.ac.ir/article-1-2263-en.html


Volume 19, Issue 5 (1-2018) Back to browse issues page
مجله ی غدد درون‌ریز و متابولیسم ایران، دو ماهنامه  پژوهشی مرکز تحقیقات غدد درون‌ریز و متابولیسم، Iranian Journal of Endocrinology and Metabolism
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