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:: Volume 19, Number 1 (6-2017) ::
2017, 19(1): 50-60 Back to browse issues page
Effect of Raisin Consumption on Some Coagulation Factors and Total Serum Antioxidant Capacity in Hyperlipidemic Patients: A Randomized Clinical Controlled Tria
farideh shishehbor, parvin joola *, nooshin Aasad Masjedi, azam Sadeghinia, amal Saki Malehi, Mohammad Ali Jalali Far, azam dehyouri
Student of M.Sc Ahvaz Jundishapur University of Medical Sciences , p.joola@yahoo.com
Abstract:   (1011 Views)

Introduction: High circulating levels of hemostatic factors are associated with increased CVD risk. Raisins contain polyphenolic compounds which can reduce risk factors for cardiovascular disease. In this study the effect of black raisin consumption on some coagulation factors, lipid profile and serum Total Antioxidant Capacity (TAC) in hyperlipidemic patients was evaluated. Materials and Methods: In this randomized clinical trial, 40 hyperlipidemic patients (25 women, 13 men), mean age of 41.05±10.4 years, participated and were randomly divided into two groups. The intervention group consumed 90 gr black raisins for 5 weeks while the control group received no intervention. Plasma levels of fibrinogen and factor VII, lipid profile and TAC were determined at baseline and after 5 weeks of intervention. Physical activity and 24-hour recall were also evaluated questionnaire at baseline and at end of the study. Data were analyzed using independent T-test and paired T-test and significant was set at P values<0.05. Results: Physical activity and energy intake did not differ significantly between the two groups. After 5 weeks of daily intakes of raisin, TAC was significantly increased in the raisin group compared to the control group (P=0.001). Although levels of lipid profile, factor VII and fibrinogen were decreased in the raisin group, they were not significant compared with control group (P=0.459, P=0.633). Mean serum total cholesterol (P=0.018) and LDL-C (P=0.01) was significantly reduced, compared to baseline, but no significant difference was observed between the two groups (P=0.797, P=0.855). Conclusion: These results indicate that consumption of black raisin which is rich in polyphenolic compounds has beneficial effects on serum antioxidant capacity in patients with hyperlipidemia.

Keywords: Black raisin, Fibrinogen, Factor VII, Antioxidant capacity, Lipid profile
Full-Text [PDF 384 kb]   (264 Downloads)    
Type of Study: Original | Subject: Nutrition
Received: 2017/01/7 | Accepted: 2017/05/17 | Published: 2017/06/10
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shishehbor F, joola P, Aasad Masjedi N, Sadeghinia A, Saki Malehi A, Jalali Far M A et al . Effect of Raisin Consumption on Some Coagulation Factors and Total Serum Antioxidant Capacity in Hyperlipidemic Patients: A Randomized Clinical Controlled Tria. Iranian Journal of Endocrinology and Metabolism. 2017; 19 (1) :50-60
URL: http://ijem.sbmu.ac.ir/article-1-2177-en.html
Volume 19, Number 1 (6-2017) Back to browse issues page
مجله ی غدد درون‌ریز و متابولیسم ایران، دو ماهنامه  پژوهشی مرکز تحقیقات غدد درون‌ریز و متابولیسم، Iranian Journal of Endocrinology and Metabolism
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