Introduction: The purpose of present study was to evaluate the role of perceived social support and resilience in predicting quality of life in patients with type 2 diabetes in Lamerd, Iran. Materials and Methods: The population of this study included all patients with type 2 diabetes who had documented information in the SedigheTahere Health Services Center of Lamerd. From among these patients, 234 were selected by the simple random sampling method. Data collection tools used in this study were the Multidimensional Scale of Perceived Social Support (MSPSS), the Resilience Scale (RS) and the World Health Organization Quality of Life (WHOQOL-BREF). This study was conducted based on the descriptive correlation method. Pearson correlation and regression analysis were used to analyze data. Results: Results of Regression analysis suggested that resilience, the support of friends and individual support predicted 46 percent of the variance in quality of life, demonstrating there was a positive and significant relationship between dimension perceived social support and resilience with quality of life. Conclusion: Considering the fact that support of friends and individual support and resilience are meaningful predictors of quality of life, promotion and enhancement of such factors can positively influence the quality of life in patients with type 2 diabetes.