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:: Volume 18, Issue 2 (7-2016) ::
2016, 18(2): 112-119 Back to browse issues page
The Effect of Hydroalcoholic Extract of Nectaroscordum Tripedale on Liver and Kidney Functional Parameters in Streptozotocin-induced Diabetic Male Rats
Sedigheh Paydar , Gholam Ali Jelodar Dr, Jamshid Mohammadi Dr *, Nastaran Mohammadi
Associate professor Yasuj University of Medical Sciences , j_mohammadi2005@yahoo.com
Abstract:   (2035 Views)

Introduction: The reducing effects of some of tripedale family plants on blood glucose, lipids and enzymes have been reported. The aim of the present study was to assess the effects of the hydroalcoholic extract of Nectaroscordum tripedale on liver and kidney function in streptozotocin-induced diabetic rats. Materials and Methods: Forty male rats were randomly divided into five groups (n=8 each). Groups 1, 3 (normal control and diabetic control) received distilled water, group 2 received 50 mg/kg/day Nectaroscordum tripedale extract, and the groups 4 and 5 (treatment groups 1 and 2) received 50 and 100 mg/kg/day of the Nectaroscordum tripedale extract respectively for  21 consecutive days. Diabetes was induced by a single injection of streptozotocin in rats. At the end of the 21st day, blood samples were collected by heart puncture. Serum levels of ALP, AST, ALT, Alb, BUN, creatinine and urea were evaluated. Results: Results showed that the hydroalcoholic extract of Nectaroscordum tripedale can increase the average body weight in the treatments groups. ALP, AST, ALT, BUN levels decreased, wherease level of albumin (Alb) increased in a dose-dependent manner at the end experimental period (P<0.05). Conclusion: Our results showed that the extract of Nectaroscordum tripedale improved liver and kidney function in a dose dependent manner in experimental conditions.

Keywords: Diabetes Mellitus, Nectaroscordum tripedale, Liver, Kidney, Rat
Full-Text [PDF 322 kb]   (678 Downloads)    
Type of Study: Original | Subject: Endocrinology
Received: 2016/01/2 | Accepted: 2016/04/26 | Published: 2016/07/16
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Paydar S, Jelodar G A, Mohammadi J, Mohammadi N. The Effect of Hydroalcoholic Extract of Nectaroscordum Tripedale on Liver and Kidney Functional Parameters in Streptozotocin-induced Diabetic Male Rats. Iranian Journal of Endocrinology and Metabolism. 2016; 18 (2) :112-119
URL: http://ijem.sbmu.ac.ir/article-1-2043-en.html
Volume 18, Issue 2 (7-2016) Back to browse issues page
مجله ی غدد درون‌ریز و متابولیسم ایران، دو ماهنامه  پژوهشی مرکز تحقیقات غدد درون‌ریز و متابولیسم، Iranian Journal of Endocrinology and Metabolism
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