Introduction: Hypoglycemia is a medical emergency that disrupt routine life. Hypoglycemia experience likely causes fear of its recurrence. Even mild or moderate episodesmay worry patients for frequent events. Limited studies have assessed predictors offear of hypoglycemia in patients with diabetes. The aim of the present study was to determine the predictingfactors of hypoglycemia in type 2 diabetic patients treated with oral anti-hyperglycemic agents. Materials and Methods: This cross-sectional study was conducted on 357 patients with type 2 diabetes treated with oral anti-diabetic drugs. Data was collected throughinterviews by using a three-part questionnaire (socio-demographic & clinical characteristics, HFS-II). The data was analyzed with descriptive and deductive statistic methods (Generalized Linear Models) at α<0.05 using SPSSv.16 software. Results: Mean age of patients was 54.11±11.54 years and the majority were female (56.6%). The mean HFS score was 16.8±16.33. In regression analysis, frequency of hospitalization (p<0.001), employment (p<0.048), number of medications (p<0.029), hyperlipidemia (p<0.026), hypoglycemia (p<0.001) and hypoglycemia intensity (p<0.001) were related to fear of hypoglycemia. Conclusion: According to the results of the present study, hypoglycemia and its intensity areconsidered as the strongest predictors of fear of hypoglycemia. Therefore, prevention of hypoglycemia occurrence and reductionof its related fear can be performed by modifying the other predictors identified in this study.