Mimetical Signs and Symptoms of Thyroid Disorders in Healthy Pregnant Women, a Population Based Study
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Sima Nazarpour , Fahimeh Ramezani Tehrani , Masoumeh Simbar , Maryam Tohidi , Hamid Alavi Majd , Fereidoun Azizi  |
Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences , fah.tehrani@gmail.com |
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Abstract: (9753 Views) |
Introduction: Although for thyroid
disorders are the second most prevalent endocrine abnormalities among
reproductive aged women, the signs and symptoms of thyroid disease can often be
masked by the physiologic changes of pregnancy. The aim of this study was to
identify physiological signs and
symptoms common to both pregnancy and thyroid disorders among a community based
sample of pregnant women without thyroid dysfunction. Materials and Methods:
This population-based cross-sectional study was conducted on 1600 pregnant
women. A comprehensive questionnaire including questions regarding the signs
and symptoms of thyroid disease was completed for subjects and relevant
clinical examinations were conducted. Blood samples were taken and serum
thyroxine (T4), T-uptake, thyrotropin (TSH) and thyroid peroxidase antibodies
(TPO-Ab) were measured. Results: Of study participants, 63.5% had normal
thyroid function. The prevalence of overt hypothyroidism and hyperthyroidism
were 3.8%, and 0.8%, respectively and 29.8% of patients had subclinical
hypothyroidism. Of pregnant women without thyroid dysfunction, 64.8% had one or
more of the signs and symptoms of thyroid disorders. Most common symptoms were
fatigue (30.3%), followed by lethargy and drowsiness (20.3%). Conclusion:
Normal physiological changes of pregnancy can mimic some of the signs and
symptoms of thyroid disorders. The results indicated that over half of the healthy
pregnant women experienced one or more of the signs and symptoms of thyroid
disorders during pregnancy. Correct interpretation of signs and symptoms of
thyroid dysfunction during normal pregnancy is critical to discriminate between
physiologic and pathological changes. |
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Keywords: Thyroid dysfunction, Signs, Symptoms, Hyperthyroidism, Hypothyroidism, Pregnancy |
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Full-Text [PDF 322 kb]
(2352 Downloads)
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Type of Study: Original |
Subject:
Endocrinology Received: 2015/04/10 | Accepted: 2015/06/17 | Published: 2015/09/16
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