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:: Volume 17, Issue 6 (3-2016) ::
2016, 17(6): 435-439 Back to browse issues page
The Effect of L-Carnitine and 10 Weeks of Aerobic Exercise on Serum Levels of CRP in Streptozotocin-induced Diabetic Rats
Mohsen Jalili, Ali Heydarianpour Dr.
Faculty of Physical Education & Sport Sciences, Bu-Ali Sina University, Hamedan , heydarian317@gmail.com
Abstract:   (7077 Views)


Introduction: Cardiovascular complications are considered as the main cause of morbidity and mortality in patients with diabetes mellitus. The role of increased serum concentrations of inflammatory markers, particularly C Reactive Protein (CRP), in the prediction and the pathogenesis of cardiovascular complications of type 1 diabetes has been established. The aim of the present study was to evaluate the effect of 10 weeks of L-carnitine supplementation and aerobic exercise training on serum levels of CRP in streptozotocin-induced diabetic rats. Materials and Methods: Male wistar rats (n=36), weighing 230±10 (grams) were randomly divided into 6 groups (n=6 each), including the healthy group, and the remaining (after the induction of diabetes mellitus by injection of streptozotocin), into the diabetic pre-test, diabetic control, diabetic aerobic training, diabetic oral L-carnitine treatment, and the diabetic aerobic training plus oral L-carnitine treatment groups. At the end of the interventions, blood samples were collected to determine serum levels of CRP. Data were analyzed with one-way ANOVA and Tukey's post hoc test using SPSS version 20; P values<0.05 were considered significant. Results: Althought L-carnitine supplem­entation in diabetic oral L-carnitine treatment group did not significantly reduce serum levels of CRP, compared with the diabetic control group (p=0.078), it however reduced the rate of its progressive increase. Also significant reductions in CRP levels in both the aerobic training (p=0) and the aerobic training plus L-carnitine supplementation groups (p=0) were observed. However, the percentage changes of CRP level in the latter group was higher. Conclusion: Results of the current study show that, aerobic training can reduce serum CRP levels in streptozotocin-induced diabetic rats, and the simultaneous use of L-carnitine supplementation, can lead to more beneficial effects.

Keywords: Type 1 Diabetes mellitus, Cardiovascular Complications, CRP, Aerobic Training, L-Carnitine
Full-Text [PDF 289 kb]   (1739 Downloads)    
Type of Study: Original | Subject: Exercise
Received: 2015/03/13 | Accepted: 2016/01/12 | Published: 2016/03/16
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jalili M, Heydarianpour A. The Effect of L-Carnitine and 10 Weeks of Aerobic Exercise on Serum Levels of CRP in Streptozotocin-induced Diabetic Rats. Iranian Journal of Endocrinology and Metabolism. 2016; 17 (6) :435-439
URL: http://ijem.sbmu.ac.ir/article-1-1915-en.html

Volume 17, Issue 6 (3-2016) Back to browse issues page
مجله ی غدد درون‌ریز و متابولیسم ایران، دو ماهنامه  پژوهشی مرکز تحقیقات غدد درون‌ریز و متابولیسم، Iranian Journal of Endocrinology and Metabolism
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