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:: Volume 17, Number 3 (9-2015) ::
2015, 17(3): 206-214 Back to browse issues page
A Comparison of Lecithin Cholesterol Acyltransferase Gene Variation among Individuals with High and Low HDL Levels in Tehran Lipid and Glucose Study (TLGS)
Dr Mohsen Naseri, Dr Mehdi Hedayati, Dr Maryam Sadat Daneshpour, Dr Fatemeh Bandarian, Dr Fereidoun Azizi *
Professor Shahid Beheshti University of Medical Sciences , azizi@endocrine.ac.ir
Abstract:   (2841 Views)

Introduction: Disturbances in blood lipids levels are considered an important risk factor for cardiovascular diseases. Low serum level of HDL-C is one of these disturbances. Therefore, identifying the genes effective on HDL levels is very important. The present study investigated the relationship between LCAT gene sequence alterations and serum levels of HDL-C. Materials and Methods: Using the data of phase 4 of the TLGS study, individuals with low serum HDL-C and individuals with high serum HDL-C were identified and individual aged ≥15 from both groups, who had at least one first degree relative with the desired phenotype were finally enrolled in the study. For each Individual confounding factors, including BMI, age, sex, blood sugar and blood pressure, were determined. LCAT gene variants were determined through direct sequencing, and their relationship with HDL-C level was investigated in the Tehran lipid and glucose study (TLGS). Results: In total, 15 variants were identified. Two variants of rs5923 and Q177E, with allelic frequencies of 5.87% and 4.7%, respectively, were identified in both groups, although, they were significantly higher in the low HDL subjects. Eleven variants were reported for the first time, while 4 variants had already been reported in the SNP database. Conclusions: Exon regions of the LCAT gene in Tehran's population have various gene variants. Although the prevalence of a number of single nucleotide variants of this gene was higher in individuals with low serum HDL-C, after adjustment for confounding factors, the difference was not statistically significant.

Keywords: Polymorphism, Single Nucleotide - Lipoprotein – LCAT- Sequence Analysis, DNA
Full-Text [PDF 465 kb]   (632 Downloads)    
Type of Study: Original | Subject: Genetic
Received: 2015/01/2 | Accepted: 2015/07/15 | Published: 2015/09/16
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Naseri M, Hedayati M, Daneshpour M S, Bandarian F, Azizi F. A Comparison of Lecithin Cholesterol Acyltransferase Gene Variation among Individuals with High and Low HDL Levels in Tehran Lipid and Glucose Study (TLGS). Iranian Journal of Endocrinology and Metabolism. 2015; 17 (3) :206-214
URL: http://ijem.sbmu.ac.ir/article-1-1866-en.html
Volume 17, Number 3 (9-2015) Back to browse issues page
مجله ی غدد درون‌ریز و متابولیسم ایران، دو ماهنامه  پژوهشی مرکز تحقیقات غدد درون‌ریز و متابولیسم، Iranian Journal of Endocrinology and Metabolism
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