A Comparison of Lecithin Cholesterol Acyltransferase Gene Variation among Individuals with High and Low HDL Levels in Tehran Lipid and Glucose Study (TLGS)
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Mohsen Naseri , Mehdi Hedayati , Maryam Sadat Daneshpour , Fatemeh Bandarian , Fereidoun Azizi  |
Shahid Beheshti University of Medical Sciences , azizi@endocrine.ac.ir |
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Abstract: (9315 Views) |
Introduction: Disturbances in blood lipids levels are considered an
important risk factor for cardiovascular diseases. Low serum level of HDL-C is
one of these disturbances. Therefore, identifying the genes effective on HDL
levels is very important. The present study investigated the relationship
between LCAT gene sequence alterations and serum levels of HDL-C. Materials and Methods: Using the data of phase 4
of the TLGS study, individuals with low serum HDL-C and individuals with high
serum HDL-C were identified and individual aged ≥15 from both groups, who had at least one first degree relative
with the desired phenotype were finally enrolled in the study. For each
Individual confounding factors, including BMI, age, sex, blood sugar and blood
pressure, were determined. LCAT gene variants were determined through direct
sequencing, and their relationship with HDL-C level was investigated in the Tehran
lipid and glucose study (TLGS). Results: In total, 15 variants were identified. Two variants of
rs5923 and Q177E, with allelic frequencies of 5.87% and 4.7%, respectively,
were identified in both groups, although, they were significantly higher in the
low HDL subjects. Eleven variants were reported for the first time, while 4
variants had already been reported in the SNP database. Conclusions: Exon
regions of the LCAT gene in Tehran's population have various gene variants.
Although the prevalence of a number of single nucleotide variants of this gene
was higher in individuals with low serum HDL-C, after adjustment for
confounding factors, the difference was not statistically significant. |
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Keywords: Polymorphism, Single Nucleotide - Lipoprotein – LCAT- Sequence Analysis, DNA |
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Full-Text [PDF 465 kb]
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Type of Study: Original |
Subject:
Genetic Received: 2015/01/2 | Accepted: 2015/07/15 | Published: 2015/09/16
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