Combined Effect of Aerobic Training and Pistacia Athlantica Extract on GLUT-4 Protein Expression and Muscle Glycogen in Diabetic Rats
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Mahmoud Zarekar , Marziyeh Saghebjoo , Mohsen Foadodini , Mehdi Hedayati ![](./files/0allsites/images/pubmed20.png) |
University of Birjand , m_saghebjoo@birjand.ac.ir |
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Abstract: (9406 Views) |
Introduction: The effects of exercise
training on GLUT4 protein expression have been examined in several studies whereas
those of aerobic training along with the use of plant extracts on muscle GLUT4
protein expression are unknown. The aim of the present study was to investigate
the effects of aerobic training and Pistacia athlantica extract on GLUT4
protein expression and glycogen
level in the gastrocnemius muscle of diabetic rats. Materials and Methods:
Forty-male Wistar rats were randomly divided into five groups: Healthy control,
diabetic control, diabetic+aerobic training, diabetic+extract and
diabetic+aerobic training+extract. The program included six weeks of aerobic
training on the treadmill. Forty eight hours after last session of training and
consumption the extract, the rats were anesthetized and gastrocnemius muscle
was isolated for measurement of glycogen levels and GLUT4 protein expression.
Data was analyzed by using one-way ANOVA test (P<0.05). Results:
GLUT4 protein expression and glycogen levels in gastrocnemius muscle in
diabetic+aerobic training+extract group were significantly higher than in the diabetic
control group (P values 0.001, 0.02 respectively), whereas these variables in the
aerobic training and the Pistacia athlantica extract perse groups did not
change compared to the diabetic control group. Conclusions: It seems
that Pistacia athlantica extract along with specific exercises, compared to
utilization of each of strategies perse, are more effective in increasing
glucose transporter proteins and possibly improving insulin function. |
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Keywords: Aerobic training, Pistacia athlantica extract, GLUT4 protein, Muscle glycogen, Diabetic rat |
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Full-Text [PDF 332 kb]
(2586 Downloads)
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Type of Study: Original |
Subject:
Exercise Received: 2014/03/17 | Accepted: 2014/08/2 | Published: 2014/10/11
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