A Review of Hyperthyroidism Models in Mouse and Rat
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Jalal Zaman , Sajjad Jeddi , Saleh Zahediasl , Asghar Ghasemi  |
Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, I.R. , Ghasemi@endocrine.ac.ir |
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Abstract: (9031 Views) |
Introduction: Humans can rarely be
used as experimental models in medical researches, because of ethical issues.
Therefore, some animal models, which have physiological systems similar to
humans, are commonly used. In this regard, rats and mice are the most favorable
species in research models. The thyroid gland has a key role in human growth
and development and is essential for normal functioning of the body systems and
tissues. The aim of this study was to review rat and mouse models of
hyperthyroidism. Materials and Methods: Related articles published between
1975-2014 on hyperthyroidism in rat and mice were searched in Pub Med. Results:
Hyperthyroidism can be induced in animals using different doses of thyroid
hormons (T3 and T4) by oral administration, injection, or with the diet. In
addition, transgenic mice could act as a model of hyperthyroidism for the
design of specific model of hyperthyroidism, such as Graves' disease. Conclusions:
Animal models of hyperthyroidism could be used for studying the disease,
treatment and identification of the molecular mechanisms involved. Pharmacologic
agents are mostly used for creating animals models of hyperthyroidism because
of their easy availability and low cost, compared to genetic techniques that
are costly and expensive. |
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Keywords: Animal models, Hyperthyroidism, Rat, T3 and T4 |
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Full-Text [PDF 316 kb]
(3507 Downloads)
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Type of Study: Review |
Subject:
Endocrinology Received: 2013/12/17 | Accepted: 2014/03/10 | Published: 2014/07/12
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