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:: Volume 16, Number 3 (9-2014) ::
2014, 16(3): 205-210 Back to browse issues page
Effect of six weeks endurance training on tumor tissue IL-10 cytokine levels in breast cancer bearing mice
Yaghoub Shiri, Hamid Agha-Alinejad *, Reza Gharakhanlou, Sadegh Amani Shalamzari, Mohammad Amin Saei
Associat professor of Exercise Physiology Tarbiat Modares University , halinejad@modares.ac.ir
Abstract:   (3154 Views)
Background: The aim of this study was evaluate the effects of endurance training on tissue IL-10 cytokine level in breast cancer bearing mice. Methods: The twenty female Balb/c mice (6-8 week-old, 14±2 gr weights) were divided to two control and exercise groups. After orientation in the environment, estrogen-receptor dependent breast cancer cells (MC4-L2) were injected to them and exercise group performed endurance exercise for 6 weeks. After appearance of the tumor, the length and width of the tumor were measured by a digital caliper once a week. Finally, the mice were sacrificed tumor tissue was removed and immediately frozen and kept in -70°C. Tumor sample was homogenized and levels of IL-10 were measured and quantified using ELISA method. Results: There was significant increase on level of IL-10 in exercise group than control group (P≤0.05). Tumor volume reduced in exercise group than control group. The results showed that the amount of IL-10 significantly increased in the exercise group compared to control group Also reduction in tumor volume observed in the exercise group compared to control group. Conclusion: Increased levels of IL-10 was in parallel to reduction in tumor volume, which shows that exercise lead to reduction tumor growth through increased levels of this cytokine. Angiogenesis is a prerequisite for continued growth and spread of tumors, therefore, increased levels of IL-10 that is an angiogenesis cytokine in the exercise group compared to the control group shows exercise can inhibit from tumor growth by modulating cytokine profile within the tumor microenvironment.
Keywords: Breast cancer, endurance training, interleukin-10, tumor volume
Full-Text [PDF 280 kb]   (1297 Downloads)    
Type of Study: Original | Subject: Exercise
Received: 2013/08/23 | Accepted: 2014/05/14 | Published: 2014/09/9
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Shiri Y, Agha-Alinejad H, Gharakhanlou R, Amani Shalamzari S, Saei M A. Effect of six weeks endurance training on tumor tissue IL-10 cytokine levels in breast cancer bearing mice. Iranian Journal of Endocrinology and Metabolism. 2014; 16 (3) :205-210
URL: http://ijem.sbmu.ac.ir/article-1-1592-en.html
Volume 16, Number 3 (9-2014) Back to browse issues page
مجله ی غدد درون‌ریز و متابولیسم ایران، دو ماهنامه  پژوهشی مرکز تحقیقات غدد درون‌ریز و متابولیسم، Iranian Journal of Endocrinology and Metabolism
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