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The Effect of Ascorbic Acid Injection into the Nucleus Accumbens Shell on Food Intake and Body Weight in Male Rats
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Firuzeh Badreh   , Mehdi Abbasnejad , Fatemeh Masjedi |
| Department of Biology, Faculty of Science, Shahid Bahonar University, Kerman, IR.IRAN , Firuze.badre@yahoo.com |
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Abstract: (9437 Views) |
| Introduction: Several factors such as dopamine affect food intake and appetite. Release of dopamine from dopaminergic neurons is associated with ascorbic acid (AA). The nucleus accumbens via direct and indirect anatomical connections with the lateral hypothalamus is effective in control of feeding behavior. Based on these observations, the aim of the present study was to investigate the effect of central injection of ascorbic acid into the nucleus accumbens shell on the food intake and body weight of adult male rats. Materials and Methods: Thirty five adult male rats were divided into five groups as follows (n=7 each): Control, sham (injected vehicle of AA), and Ascorbic Acid (AA) groups (10, 50, and 250 µg/rat). Rats were anaesthetized and cannulas were implanted bilaterally in the nucleus accumbens shell (AP= 1.7 mm, LA= ±0.8 mm from bregma, DV=5.6 mm from skull surface). After one week recovery period, three different doses of ascorbic acid (1 μl/day) were injected into the three separate groups for 4 days. Food intakes were measured every 24 hours and weight changes were determined after 4 days. Results: Doses of ascorbic acid (10, 50, and 250 µg/rat) decreased food intake significantly (p<0.01). Although the partial decrease was observed in the body weight, but the decrease was not significant in any of the different doses groups. Conclusion: Based on our results, it seems that ascorbic acid in the nucleus accumbens shell, probably via hunger and the satiety control centers in the hypothalamus, regulates body weight and food intake. |
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| Keywords: Ascorbic acid, Nucleus accumbens, Food intake, Body weight, Rat |
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Full-Text [PDF 301 kb]
(2188 Downloads)
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Type of Study: Original |
Subject:
Nutrition
Received: 2011/09/12 | Accepted: 2012/04/4 | Published: 2012/09/15
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Badreh F, Abbasnejad M, Masjedi F. The Effect of Ascorbic Acid Injection into the Nucleus Accumbens Shell on Food Intake and Body Weight in Male Rats. Iranian Journal of Endocrinology and Metabolism 2012; 14 (3) :289-295 URL: http://ijem.sbmu.ac.ir/article-1-1245-en.html
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