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:: Editorial Board
:: About Iranian Journal of Endocrinology and Metabolism
:: Volume 13, Issue 4 (11-2011) ::
2011, 13(4): 398-405 Back to browse issues page
Folate and Vitamin B12 Intake and Risk of Squamous-cell Carcinoma of the Esophagus
B Hajizadeh , S Mirzaeian , B Rashidkhani
Shahid Beheshti University of Medical Sciences , b_rashidkhani@sbmu.ac.ir
Abstract:   (33260 Views)

Introduction: Esophageal cancer is one of the most common cancers in Iran and has a high mortality rate. The aim of this study was to assess the association between folate and vitamin B12 intake and risk of squamous-cell carcinoma of the esophagus cancer. Materials and Methods: In this case-control study, cases (n=47) were patients diagnosed with squamous-cell carcinoma of the esophagus (SCCE) in main hospital Kurdistan and controls (matched with cases by age and sex) were patients with acute non-cancer diseases at the same hospitals (n=96). Demographic data and physical activity were collected using questionnaires. A semi-quantitative food frequency questionnaire used for nutritional information and folate and vitamin B12 intake were calculated with Nutritionst IV (N4). Results: Thirty eight percent of cases and 40% of controls were males. Mean age of cases and controls were 58±18 and 58±17 years respectively. Mean folate intake among cases was 152.1 μg/day, which was less than in the controls. After adjustment for confounders, folate intake was inversely related with SCCE (OR=0.03, 95% CI 0.00, 0.12). The association between vitamin B12 intake and SCCE was not significant (p=0.46). Conclusion: Folate intake was inversely related with SCCE: however, there was not a significant association between vitamin B12 intake and SCCE.

Keywords: Squamous-cell carcinoma, Esophagus, Folate, B12, Food intake
Full-Text [PDF 294 kb]   (3875 Downloads)    
Type of Study: Original | Subject: Nutrition
Received: 2011/01/27 | Accepted: 2011/06/14 | Published: 2011/11/15
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hajizadeh B, mirzaeian S, rashidkhani B. Folate and Vitamin B12 Intake and Risk of Squamous-cell Carcinoma of the Esophagus . Iranian Journal of Endocrinology and Metabolism 2011; 13 (4) :398-405
URL: http://ijem.sbmu.ac.ir/article-1-1105-en.html


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Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
Volume 13, Issue 4 (11-2011) Back to browse issues page
مجله ی غدد درون‌ریز و متابولیسم ایران، دو ماهنامه  پژوهشی مرکز تحقیقات غدد درون‌ریز و متابولیسم، Iranian Journal of Endocrinology and Metabolism
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