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Evaluation of Serum Levels of IL-1α, TGF-β, TNF-α, IFN-α, IFN-γ, Cortisol and Immunoglobulins in Islamic Ramadan Fasting
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F. Sharifi   , A. Masoud , M. Rezai , M. Ziaei , M. Hedayati |
| , masood2002@yahoo.com |
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Abstract: (31432 Views) |
| Introduction: This research aimed determining the levels of cortisol, immunoglobulins and major serum cytokines, following Ramadan fasting, as immune response indexes. Materials and Methods: For this before and after Ramadan fasting study, twenty-five students residing at the dormitory of the Tehran University of Medical Sciences were selected. All cytokines levels (IL-1α, TGF-β, TNF-α, IFN-α, IFN-γ) were determined by the ELISA method, Immoglobulines were determined by the Radial Immunodiffusion (SRID) technique and cortisol levels were measured by EIA too. Results: While IFN-γ a showed a considerable increase after Ramadan fasting (P<0.01), IFN-α and TNF-α had decreased (P³ 0.5 and <0.02 respectively). Serum level of TGF-β increased but not significantly (P>0.3) cortisol also increased after one month of fasting (P<0.05). Serum IL-1α had a non-significant decrease (P ³ 0.5). Although IgG & IgM levels showed no significant increase, IgA levels showed significant decrease [P<0.5]. Conclusion: Our data revealed that Ramadan fasting increased IFN-y, while decreasing TNF-a and IgA levels ramadan fasting can probably increase T-Cell function, lower the inflammatory appreance rate and affect immunoglubulin production |
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| Keywords: Islamic Ramadan Fasting, Cytokine, Cortisol, Immunoglobuline |
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Full-Text [PDF 256 kb]
(5210 Downloads)
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Type of Study: Original |
Subject:
Endocrinology
Received: 2007/10/20 | Published: 2007/09/15
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