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Evaluation Effect of Silybum Marianum, Cynara Scolymus L. and Ziziphus jujube Mill. Combination Extract on Non-alcoholic Fatty Liver in Rats
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Mojgan Mohammadifar   , Mohammad Behnam , Sayyed Alireza Talaei , Tahereh Khamechian , Medi Mehran , Mohsen Taghizadeh |
| Biochemistry and Nutrition in Metabolic Diseases Research Center , taghizadeh_m@kaums.ac.ir |
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Abstract: (12701 Views) |
| Introduction: Non-alcoholic fatty liver disease includes a spectrum of clinical syndromes from early steatosis to liver cirrhosis. The aim of this study was to evaluate the effect of combined extract of silymarin, artichoke and jujube on non-alcoholic fatty liver, induced by high-fat diet in rats. Materials and Methods: In this experimental study, 40 male rats were divided randomly into two groups, a sham group (n=8) and a high-fat diet group (n=32). After 4 months of being fed the high-fat diet, rats suffering from fatty liver were divided into 4 groups (n=8 each) including a high-fat diet group and the three groups receiving a dose of the combined extract 100, 200 and 400 mg/kg for 2 months. Finally, lipid profiles, activity of serum liver enzymes and liver histology were investigated. Results: The high-fat diet increased Chol, TG and LDL and decreased HDL levels (P<0.001). This diet also increased serum activity of ALT, AST and ALP to 84, 113 and 228 %, respectively. Receiving extract at doses of 200 and 400 mg/kg improved lipid profiles and hepatic enzyme activity (P<0.05). Histopathology confirmed changes in liver induced by the high fat diet and the protective effect of the extract. Conclusion: High-fat diet induced nonalcoholic fatty liver in rats and treatment with combined extracts of silymarin, artichoke and jujube improved the complications of the disease. |
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| Keywords: Silybum Marianum, Cynara scolymus, Ziziphus jujube, Non-alcoholic fatty liver, High-fat diet |
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Full-Text [PDF 789 kb]
(2046 Downloads)
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Type of Study: Original |
Subject:
Nutrition
Received: 2017/07/23 | Accepted: 2017/12/23 | Published: 2018/03/14
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