:: Volume 15, Issue 1 (6-2013) ::
2013, 15(1): 59-66 Back to browse issues page
Effect of Supplementation with Grape Seed Extract (Vitis vinifera) on Serum Lipid Profiles in Patient with Type 2 Diabetes
Somayeh Abedini , Bahram Poorghasem , Hossein Babaei , Akbar Aliasgarzadeh , Parvin Poorabdollahi
Department of Biochemistry & Nutrition , pourghassemb@tbzmed.ac.ir
Abstract:   (9519 Views)
Introduction: Lipid abnormalities are a major cause of cardiovascular diseases in patients with type 2 diabetes. The present study was therefore designed to investigate the supplemental effects of grape seed extract on serum lipid profiles of patients with type 2 diabetes. Materials and Methods: The study was a randomized, triple-blind, clinical trial in which 48 patients with type 2 diabetes were randomly assigned to 2 groups, the grape seed extract supplement and the placebo group. The patients in the grape seed extract group received 200 mg/d grape seed extract for 8 weeks while the placebo group received a corresponding placebo. At baseline and or the end of the 8th week of the study, 5 ml blood was collected after a 12 to 14-hour fast from each patient and serum triglycerides, total cholesterol, HDL-C, and LDL-C were measured. Results: There were no significant differences between the two groups with regard to mean changes of serum trigl‌ycerides, total cholesterol, HDL-C, and LDL-C. Conclusion: The results of the present study indicate that grape seed extract supplement has no effect on serum lipid profiles in patients with type 2 diabetes.
Keywords: Grape seed extract, Lipid profile, Type 2 diabetes
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Type of Study: Original | Subject: Endocrinology
Received: 2012/05/27 | Accepted: 2013/05/22 | Published: 2013/05/22

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Volume 15, Issue 1 (6-2013) Back to browse issues page