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High Prevalence Of Diabetes And Abnormal Glucose Tolerance in Urban Iranians Aged Over 20 Years: Determining an Effective Screening Strategy for Un-diagnosed Diabetes
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F Hadaegh   , M Bozorgmanesh , H Harati , N Saadat , F Azizi |
| , fzhadaegh@ endocrine.ac.ir |
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Abstract: (31644 Views) |
| Introduction: The aim of this study was to determine the prevalences of diagnosed and undiagnosed diabetes mellitus, impaired fasting glucose (IFG), impaired glucose tolerance (IGT), and combined IFG/IGT and to develop an effective screening strategy for undiagnosed diabetes in a large urban Iranian community. Materials and Methods: The study population included 9,519 participants of the Tehran Lipid and Glucose Study, aged ≥ 20 years, with full relevant clinical data. Age-standardized prevalence of diabetes and glucose intolerance categories were reported according to the 2003 American Diabetes Association definitions. The numbers needed to screen (NNTS) to find one person with undiagnosed diabetes were estimated from age-adjusted logistic regression models. Results: The prevalences of diagnosed and undiagnosed diabetes, isolated IFG, isolated IGT, and combined IFG/IGT were 8.1%, 5.1%, 8.7%, 5.4% and 4.0% in men and 10%, 4.7%, 6.3%, 7.6%, and 4.5% in women respectively. Un-diagnosed diabetes was associated with family history of diabetes, increased body mass index (BMI ≥ 25 kg/m2), abdominal obesity, hypertriglyceridemia, hypertension and low HDL-C levels. Among men, a combination of increased BMI, hypertension, and family history of diabetes led to an NNTS of 1.6 (95%CI: 1.57-1.71) and among women a combination of family history of diabetes and abdominal obesity, yielded an NNTS of 2.2 (95%CI: 2.1-2.4). Conclusions: Approximately 32% of Tehranian adults had either diabetes or some degree of other glucose tolerance abnormalities. Nearly 40% of total cases with diabetes were undiagnosed. Screening individuals with family history of diabetes, BMI25 kg/m2, abdominal obesity and hypertension may have substantial advantages. |
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| Keywords: Type 2 diabetes, IFG, IGT, Undiagnosed diabetes, Screening |
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Full-Text [PDF 356 kb]
(5085 Downloads)
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Type of Study: Original |
Subject:
Endocrinology
Received: 2008/05/13 | Published: 2008/03/15
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