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The Effect of Progressive Resistance Training on Omentin-1 Concentration, Inflammatory Indices, and Insulin Resistance in Overweight Men
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J Almasi    , ME Hasani tabatabaei , K Ranjbar |
| Department of Exercise Physiology, BA.C., Islamic Azad University, Bandar Abbas, I.R. Iran , kamal_ranjbar@iau.ac.ir |
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Abstract: (190 Views) |
Introduction: Omentin-1 acts as a key mediator linking adipose tissue to glucose homeostasis. Since exercise training is recognized as an effective non-pharmacological strategy for the management of obesity and overweight, the present study aimed to investigate the effects of eight weeks of resistance training on serum omentin-1 levels, inflammatory markers, lipid profile, and insulin resistance in overweight men. Materials and Methods: Thirty-four overweight young men aged 25–35 years were randomly assigned to either a control (BMI=29.3±1.5) or training (BMI=29.1±1.7) group. The training group performed progressive resistance training for 8 weeks, three sessions per week, at 60–80% of one-repetition maximum, while the control group maintained a sedentary lifestyle. Blood samples were collected at baseline and post-intervention and analyzed using ELISA and validated diagnostic kits. Data were analyzed using analysis of covariance (ANCOVA). Results: Resistance training, despite no significant changes in body weight or BMI, led to reductions in body fat percentage and waist-to-hip ratio. In addition, LDL-C, triglycerides, and total cholesterol levels decreased, while HDL-C and nitric oxide levels increased. Inflammatory markers, including IL-6, TNF-α, and hs-CRP, showed significant reductions. Interestingly, omentin-1 levels significantly decreased following training. Conclusion: Eight weeks of resistance training improved inflammatory and lipid markers as well as insulin resistance in overweight men. However, contrary to expectations, a reduction in omentin-1 levels was observed, suggesting that more complex mechanisms are involved in the regulation of this adipokine in response to resistance training.
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| Keywords: Overweight, Resistance training, Omentin-1, Insulin Resistance, Inflammation |
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Full-Text [PDF 1455 kb]
(128 Downloads)
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Type of Study: Original |
Subject:
Exercise
Received: 2025/08/19 | Accepted: 2025/12/21 | Published: 2025/03/30
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