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The Effect of Aerobic Training and Aged Garlic Extract Supplementation on Plasma Fetuin-A Levels and Insulin Resistance in Obese Male Rats
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P Khabiri    , MR Rahimi , I Rashidi , ٍُُSE Nedaei |
| Department of Exercise Physiology, University of Kurdistan, Sanandaj, Iran, , p.khabiri@uok.ac.ir |
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Abstract: (668 Views) |
Introduction: This study aimed to investigate the effect of aerobic training (AT) and aged garlic extract (AGE) supplementation on plasma fetuin-A levels and insulin resistance. Materials and Methods: Forty male Sprague-Dawley rats were exposed to high-fat (n=32) and standard (n=8) diets for 9 weeks. Obesity induced in the high-fat diet group and they were divided into 4 subgroups: the obese control (OC), supplementation with AGE, AT, and supplementation with AGE+AT; interventions were performed for 8 weeks in this group. The rats of the group fed with a standard diet (C) continued the diet for 8 weeks. The AGE supplementation was fed to rats once daily at a dose of 600 mg/kg by gavage. Aerobic training included running on a treadmill 5 days a week. Blood samples were collected and plasma levels of fetuin-A, insulin, and glucose were measured 48 hours after the last interventions and after 12 hours of fasting. Results: Plasma fetuin-A levels showed a significant reduction following all interventions (AGE, AT, AGE+AT) compared to the OC group (26.38±4.42, 19.8%, 22.87±3.50, 30.5%, 17.21±2.20, 47.7%, respectively, compared to 32.93±6.56; P=0.020, P=0.001, P=0.001, respectively). Plasma insulin also showed a significant decrease following all interventions (1.04±0.13, 33.3%, 0.73±0.15, 53.2%, 0.66±0.13, 57.6%, respectively, compared to 1.56±0.13; all interventions P=0.001). Plasma glucose showed a significant decrease only following AGE+AT (112.65±6.20 compared to 127.60±7.85, 11.7%; P=0.001). Insulin resistance also showed a significant decrease following all interventions (0.31±0.04, 36.7%, 0.22±0.04, 55.1%, 0.18±0.04, 63.2%, respectively, compared to 0.49±0.04; all interventions P=0.001). Conclusion: Both supplementation with AGE and AT seem effective in reducing plasma fetuin-A and improving insulin resistance. However, AT alone and the combination of AT+supplementation with AGE showed more effects compared to supplementation with AGE.
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| Keywords: Exercise training, Obesity, Hepatokine, Aged garlic extract |
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Full-Text [PDF 986 kb]
(481 Downloads)
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Type of Study: Original |
Subject:
Exercise
Received: 2022/10/31 | Accepted: 2023/01/11 | Published: 2022/09/1
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