Introduction: Purine metabolism involves synthesis and degradation of purine nucleotides. Studies show that intensity of exercise affects the organ systems and their energy sorces and also  can impact on precursor sorces for adenosine triphosphate (ATP) biosynthesis. The purpose of this study was to compare two different type of wrestling exercises regarding metabolic efficiency and effectiveness of the purine nucleotide cycle indicator. Materials and Methods: Twenty one subjects division were divided according to weight, into two groups of circuit training, based on wrestling techniques (n=10) and wrestling traditional training (n=11). After performing functional tests, blood sampling was done before and after of training. The subjects performed circuit method and traditional wrestling exercise four weeks, using six wrestling techniques. Results: Results showed that circuit training based on these wrestling techniques after four weeks showed no significant differences between the two groups in levels of Hypoxanthine-guanine phosphoribosyl transferase (HGPRT) (P=0.44), Hypoxanthine (HX) (P=0.54) and plasma uric acid (UA) (P=0.51). Intra-group comparison however revealed that the circular wrestling training and traditional wrestling exercises caused significantly reduced Hypoxanthine values in circuit training (P=0.03) and traditional training (P=0.008), and also showed significant increases in aerobic and mean anaerobic power. Conclusion: Comparison of these two methods of exercise training showed that these methods did not differ and had similar effect on indicators of purine nucleotide cycle. Furthermore the results of this study confirm those of previous studies that sprint training and exercises that use anaerobic energy systems, effectively change purine metabolism and subsequently affected metabolite production.