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:: Volume 18, Issue 3 (9-2016) ::
2016, 18(3): 213-221 Back to browse issues page
Leptin and Autoimmune Diseases
Maryam Fanaei, Sayyed Hamid Zarkesh-Esfahani, Sahar Eskandari, Ghazal Babolmorad, Sarareh Harirchi, Marzieh Rezaei, Somaieh Sabzali, Mina Seifzadeh
University of Isfahan
Abstract:   (9475 Views)

Introduction: Leptin, an anti-obesity hormone, is also a regulator of the immune response which sends important signals regarding the metabolic status and immune system function. This hormone/cytokine can affect the secretion of acute phase proteins such as Interleukin-1 and TNF-α and facilitate communication between nutrition and Th1 immune response so that when the food intake reduces, plasma leptin levels decreases, leading to reduced function of the immune system. Increase in blood leptin levels in obesity makes the obese people more susceptible to cardiovascular diseases, autoimmune diseases and cancer. Previous researches demonstrate the  important effects of leptin in metabolism, whereas more recent studies show that this molecule has an important role in many other key functions of body such as haematopoiesis, thermogenesis, reproduction, angiogenesis, homeostasis and immune system. This paper aims to review the most recent findings regarding the role of leptin in the pathology of autoimmune disease, in particular multiple sclerosis, psoriasis, autoimmune thyroid disease, lupus erythematosus, endometriosis and rheumatoid arthritis.

Keywords: Leptin, Leptin receptor, Autoimmune, Immune system disorders
Full-Text [PDF 342 kb]   (3003 Downloads)    
Type of Study: Review | Subject: General
Received: 2015/12/3 | Accepted: 2016/07/11 | Published: 2016/09/6
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Fanaei M, Zarkesh-Esfahani S H, Eskandari S, Babolmorad G, Harirchi S, Rezaei M, et al . Leptin and Autoimmune Diseases. Iranian Journal of Endocrinology and Metabolism 2016; 18 (3) :213-221
URL: http://ijem.sbmu.ac.ir/article-1-2033-en.html

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Volume 18, Issue 3 (9-2016) Back to browse issues page
مجله ی غدد درون‌ریز و متابولیسم ایران، دو ماهنامه  پژوهشی مرکز تحقیقات غدد درون‌ریز و متابولیسم، Iranian Journal of Endocrinology and Metabolism
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