Introduction: Physical activity has beneficial effects in the prevention of metabolic syndrome components. The purpose of this study was to investigate the effects of circuit resistance training  on changes in  fasting blood glucose, blood fat and blood pressure in females with type II diabetes. Materials and Methods: In this study, twenty females volunteers with diabetes Type II (aged 50.2±4.8yr, BMI 30.16±3.6 kg/m2) participated and were randomly divided into a circuit resistance training and a control group aged 51.3±6.63yr, BMI 30.5±4.8 kg/m2. Circuit resistance training included of leg extensions, lying leg curl, bench press, cable triceps pushdown, frontarm, leg press, cable Row and sit-ups with 40-65 % 1RM for 3 days a week. Blood pressure and body composition was measured before starting the training protocol and after the last training session. Changes from baseline were assessed using the paired sample t-test. In addition, pre-and-post comparisons between groups were analyzed, using the independent student t-test. Results: Results showed significant changes in glycosylated hemoglobin (HbA1c) (P<0.03) and total cholesterol (TC)(P<0.02) between these two groups after intervention, whereas no significant changes occurred in fasting blood sugar, triglycerides (TG), highdensity lipoprotein (HDL-C), low-density lipoprotein (LDL-C), levels or in systolic or diastolic  blood pressure, or waist to hip ratio (WHR). Conclusions: Circuit resistance training with 40-65%1RM can decrease glycosylated hemoglobin and total cholesterol in patients and plays an important role in improving symptoms of metabolic syndrome in patients.