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Genetic Association of Some Haplotypes to Level of HDL-C, Triglyceride, and Waist in Family Members with Metabolic Syndrome Using Haplotype Based Association Test
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Nima HosseinZadeh   , Yadolah Mehrabi , Maryam Sadat Daneshpour , Hamid Alavi Majd , Fereidoun Azizi |
| Faculty of Public Health, Shahid Beheshti University of Medical Sciences , ymehrabi@gmail.com |
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Abstract: (9969 Views) |
| Introduction: Haploytpes are important elements in study of genetic associations. The haplotype based association test (HBAT) is a method to study genetic association of haplotypes with one or more traits. The test statistic in this method, which is calculated for all haplotypes, follows a standard normal distribution. In this study, in order to find the chromosomal area locus of genes affecting metabolic syndromes, the HBAT method was used to investigate the genetic association of haplotypes of some candidate microsatellites with HDL-C, triglycerides, and waist. Materials and Methods: A sum of 125 families with at least one member having metabolic syndrome according to ATPIII, and at least two members with low HDL-C levels were selected from among participants of the Tehran Lipid and Glucose Study (TLGS). The genetic association of HDL-C, triglycerides, and waist with haplotypes of some microsatellites of chromosome 8, 11, 12, and 16 was studied, using HBAT. Results: Data was obtained for 125 families, consisting of 563 individuals, aged 20 years or above (269 males and 294 females). Genetic association of the haplotype 2-2-2-2 of chromosome 8 showed significant association with HDL-C and triglycerides. Haplotypes 2-2-1 and 2-2-2 of chromosome 12 showed significant association with triglycerides. In addition, haplotype 1-1-2 of this chromosome was found to be associated with waist (P<0.05). Conclusion: Researching haplotypes provides more information on genetic associations, and identification of haplotypes influencing HDL-C level, triglycerides, and waist may be helpful in designing future research aimed at determining the genes predisposing persons to metabolic syndrome. |
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| Keywords: HBAT, Microsatellite, Haplotype, Metabolic syndrome |
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Full-Text [PDF 308 kb]
(2979 Downloads)
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Type of Study: Original |
Subject:
Genetic
Received: 2011/07/7 | Accepted: 2012/02/6 | Published: 2012/09/15
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