[Home ] [Archive]   [ فارسی ]  
:: Main :: About :: Current Issue :: Archive :: Search :: Contact ::
Main Menu
Home::
Journal Information::
Articles archive::
For Authors::
For Reviewers::
Subscription::
Contact us::
Site Facilities::
::
Search in website

Advanced Search
Receive site information
Enter your Email in the following box to receive the site news and information.
Last site contents
:: Editorial Board
:: About Iranian Journal of Endocrinology and Metabolism
:: Volume 3, Issue 1 (3-2001) ::
2001, 3(1): 11-22 Back to browse issues page
Serum lipids, lipoproteins, apolipoproteins and paraoxanase enzyme activity in patients with thyroid dysfunction
F Azizi , F Raiszadeh , M Solati , A Etemadi , M Arabi , M Rahmani
Abstract:   (30969 Views)
Abstract: Lipid and lipoprotein metabolism is affected by many factors, among them thyroid hormones. Lipid and apolipoprotein disorders are common findings in patients with thyroid dysfunction. Moreover, LDL-C oxidation is more common in these patients than the normal population. This study aims at assessing lipids, lipoproteins, apolipoproteins and serum paraoxonase activity in patients with thyroid dysfunction and comparing them with normal controls. In this study 99 patients with thyroid dysfunction (49 hypothyroid and 50 hyperthyroid) were each compared with a separately age and sex matched control group of 50. A fasting blood sample was obtained and serum total cholesterol, triglycerides, apolipoproteins A-I and B, and paraoxonase activity were measured. In hyperthyroid patients, significant reductions in serum paraoxonase activity (45±23 vs. 67±37 Iu/ml, P<0.001), triglycerides (112±53 vs. 166±130 mg/dl, P<0.05), apolipoprotein A-I (137±26 vs. 154±21 mg/dl, P<0.001) and apolipoprotein B (75±18 vs. 85±25 mg/dl, P<0.05) were found. Hypothyroid patients had lower paraoxonase activity (46±21 vs. 64±32 Iu/ml, P<0.005) than controls and higher total cholesterol (224±69 vs. 185±41 mg/dl, P<0.001), LDL-C (133±59 vs. 93±36 mg/dl, P<0.001), and apo B (107±37 vs. 84±23 mg/dl, P<0.001). The results show significant changes of lipid levels in thyroid dysfunction, like previous studies. Also, for the first time in both hypo and hyperthyroid patients we observed significant reduction in serum paraoxonase activity. According to these findings, increased LDL oxidation in thyroid dysfunction, at least to some extent, can be attributed to reduced serum paraoxonase activity.
Keywords: Paraoxonase, Lipoprotein, Apolipoprotein, Hyperthyroidism, Hypothyroidism
Full-Text [PDF 289 kb]   (5504 Downloads)    
Type of Study: Original | Subject: Endocrinology
Received: 2006/11/16 | Published: 2001/03/15
Add your comments about this article
Your username or Email:

CAPTCHA


XML   Persian Abstract   Print


Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Azizi F, Raiszadeh F, Solati M, Etemadi A, Arabi M, Rahmani M. Serum lipids, lipoproteins, apolipoproteins and paraoxanase enzyme activity in patients with thyroid dysfunction. Iranian Journal of Endocrinology and Metabolism 2001; 3 (1) :11-22
URL: http://ijem.sbmu.ac.ir/article-1-115-en.html


Rights and permissions
Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
Volume 3, Issue 1 (3-2001) Back to browse issues page
مجله ی غدد درون‌ریز و متابولیسم ایران، دو ماهنامه  پژوهشی مرکز تحقیقات غدد درون‌ریز و متابولیسم، Iranian Journal of Endocrinology and Metabolism
Persian site map - English site map - Created in 0.05 seconds with 38 queries by YEKTAWEB 4657