Introduction: Considering the controversial findings documented on the apolipoproteins A and B association as cardiovascular risk factors and the severity of CAD, this study evaluated the apoA and apoB association with severity of coronary artery disorders in an Iranian population. Materials and Methods: In a cross-sectional study 144 consecutive patients who were scheduled for coronary angiography, were divided into two groups according to severity of coronary stenosis (Mild, severe) and their medical histories and demographic data were collected. Before angiography, fasting blood samples were taken to measure fasting blood sugar, total cholesterol, triglycerides, and apoA and apoB. Based on their to angiography results, patients were divided groups one and two, with mild and severe coronary artery involvements, respectively  Aplipoprotein levels and ratio were compared by Chi -square, Fisher, logistic regression and t-student tests in both groups. Results: Mean age of groups one and two were 57.7±9.6 and 58.24±11.3 years respectively. Apoliprotein levels and apoA/apoB ratio had no significant association with severity of coronary artery disease involvements (p≥0.05), findings which remained after adjusting data for confounding variables (p≥0.05). Conclusion: Factors that affect the disease severity may differ from the etiological factors that cause the disease. Hence further studies on these are recommended.