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Showing 2 results for Thyroid Peroxidase Antibody

Dr Mehdi Hedayati, Marzieh Salehi Jahromi, Laleh Hoghoughi , Marjan Zarif Yeganeh, Dr Maryam Daneshpour, Dr Fereidoun Azizi,
Volume 13, Issue 3 (9-2011)
Abstract

Abstract

Introduction: Autoimmune thyroid diseases (AITD) are common and it is important to identify the genetic determinants. The aim of this study was to assess the relationship between two polymorphisms of Thyroid Peroxidase gene (TPO) and serum level of Anti-TPO titer in an Iranian population. Materials and methods: We selected 184 individuals from Tehran Lipid and Glucose Study, categorized as the Anti-TPO- (n=72) and Anti-TPO+ (n=112) groups. Inclusion criteria for cases was Anti-TPO and Anti-Tg>100U/L with a history of hypothyroidism. Anti-TPO levels in subjects were measured by the ELISA kit. Genomic DNA was extracted using Salting-out/Proteinase K method. Polymorphism detection of Exon 8 and 12 was done using the PCR-RFLP method. The PCR products were incubated with restriction enzymes SacII and BsrI, respectively. Results: The C allele frequency of C2145/T polymorphism Exon 12 (rs732608) was observed in 71.2% of patients and in 28.8% of normal individuals. This allele was significantly associated with increased levels of Anti-TPO [(T 140±330 pmol/L vs. C 436±380 pmol/L P<0.001), (OR: 9.2)]. The G1193/C was not associated with the level of serum Anti-TPO in this study. Conclusion: We demonstrated that the C allele polymorphism in C2145/T exon 12 is associated with high levels of serum Anti-TPO and that carriers of this allele are predisposed to disease 9.2 times more  than those who do not have A allele.


Dr Fs Saeidian , Dr F Sarvghadi, A Amouzegar, Dr L Mehran, Dr S Mahdavi, Dr Y Mehrabi, Dr F Azizi, Dr H Abdi,
Volume 25, Issue 6 (2-2024)
Abstract

Introduction: Considering the inconsistent data on the relationship between vitamin D (VD) and autoimmune thyroid diseases, we aimed to investigate associations of VD with anti-thyroid peroxidase antibody (TPOAb). Materials and Methods: For this study, 695 subjects, including 369 women, were enrolled. TPOAb status was compared between different categories of VD deficiency (VDD), and correlations between TPOAb and VD were estimated. Multiple logistic regression analysis investigated the associations between VD status and TPOAb positivity. Results: The prevalence of VDD was 82%. There was no statistically significant difference in the prevalence of TPOAb positivity among different VD groups (p-value=0.18), a finding that did not change when TPOAb titer was considered a continuous variable. Multiple logistic regression analysis showed no significant relationships between VD status and TPOAb positivity. Regarding thyroid function, a weak negative correlation between 25(OH) D and TSH in men and a weak positive correlation between 25(OH) D and FT4 in women was demonstrated. Conclusion: Our study in a population with a high prevalence of VDD revealed no statistically significant associations between serum VD levels and either TPOAb levels or TPOAb positivity.


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مجله ی غدد درون‌ریز و متابولیسم ایران، دو ماهنامه  پژوهشی مرکز تحقیقات غدد درون‌ریز و متابولیسم، Iranian Journal of Endocrinology and Metabolism
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