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Showing 2 results for Interleukin-6

Abbasali Gaeini, Abdolreza Kazemi, Ali Asghar Fallahi, Aghaali Ghasemnian,
Volume 12, Issue 4 (11-2010)
Abstract

Introduction: The purpose of this study was to determine the response of some immune and inflammatory markers of cardiovascular disease to a single, short intense duration of exrcise, in prepubertal overweight boys exercise. Materials and Methods: To do this, 13 students 11-14 years-old were selected randomly from among voluntary subjects. In the preliminary session VO2max (26.9±4.9 ml/kg/min), weight (77.07±17.33 kg), height (1.65±0.08), fat percent (31.7±5.6 percent), percent), body composition, BMI (28.9±3.5 kg/m2), skeletal age (12.4±0.9 years) with X-ray, pubertal age with Tanner-stage (T3, T4) was measured and determined familiar illness was done four day before experimental session. In the experimental session, firstly, pre-exercise blood sample collected in fasted state, and then every subject on the ergometer cycle started cycling with 65-70% VO2max for 40 min, post 5 min warming, with 5 min cool down at the end of the program. Immediately post-exercise and recovery blood samples were drawn for measurement of plasma leukocyte, C-reaction protein and IL-6. Plasma CBC and its subgroups were measured by a cell counter employing Isotone Soluble technique, while for hs-CRP and IL_6, we used the immunometric assay Eliza kit. Data were analyzed using the analysis of variance with repeated measures (R-ANOVA) test. Results: The results showed there was a significant relation between different blood samplings. The post hoc (LSD) test that showed neutrophils count and hs-CRP and IL-6 levels one hour after exercise statistically was more than pre-exercise (p=0.001, 0.01, 0.01, respectively) also lymphocyte, monocytes, neutrophils counts and IL-6 level immediately post- exercise (p=0.05, 0.01, 0.004, 0.01, respectively). Exercise may initiate the response of inflammatory and immune factors in prepubertal obese boys, and increase levels of these factors. Conclusion: This study indicates that a single intense bout of exercise with 65-70% Vo2max can increase subgroups of with blood cells, C-reactive protein and IL-6 in immature obese and overweight children, intense exercise can be activate immune and inflammatory system and increase levels of some of the cited factors.


Dr M Khalafi, F Almasi, M Aghaeinejad, Dr A Qanbarpoor Nosrati , Dr F Ghasemi,
Volume 27, Issue 1 (3-2025)
Abstract

Introduction: This meta-analysis investigates the effect of resistance training on inflammatory markers in individuals with chronic kidney disease (CKD). Materials and Methods: A compre­hensive search was conducted in PubMed, Web of Science, Scopus, Google Scholar, Magiran, and NoorMags databases for English and Persian articles published until December 2023. The inclusion criteria for the present meta-analysis included 1) human research with chronic kidney disease subjects, 2) resistance training against the control group, 3) randomized controlled trials (RCT), and 4) measurement of inflammatory factors including TNF-α, CRP, and IL-6. To determine the effect size of the effect of exercise training against the control group on inflammatory markers on TNF-α, CRP, and IL-6, standardized mean difference (SMD) and 95% confidence intervals (CIs) were calculated. Results: Twelve studies, including 908 subjects, were included in the present meta-analysis. The results showed that resistance training significantly reduced TNF-α [SMD=-0.82 (Cl:-1.33 to -0.32), P=0.001], CRP [SMD=-0.70 (Cl:-0.07 to -1.32), P=0.02], and IL-6 [SMD=-0.58 (Cl:-0.28 to -0.89), P=0.001]. Conclusion: Resistance training may improve chronic inflammation by reducing IL-6, TNF-α and CRP in patients with CKD.


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مجله ی غدد درون‌ریز و متابولیسم ایران، دو ماهنامه  پژوهشی مرکز تحقیقات غدد درون‌ریز و متابولیسم، Iranian Journal of Endocrinology and Metabolism
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