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Showing 24 results for haghighi
Seyed Ahmad Hosseini, Meysam Alipour, Mehrnoosh Zakerkish, Mohammad Hossein Haghighizadeh,
Volume 16, Issue 3 (9-2014)
Abstract
Introduction:Systemic Inflammation plays a crutal play in the development of cardiovascular disease in patients with Type 2 diabetes. The aim of this study was to investigate the effect of standardized extract of ginseng (G115) in Biomarkers of Systemic Low-Grade Inflammation in patients with Type 2 diabetes. Materials and Methods: This randomized, double-blind trial was performed on 40 patients with type 2 diabetes (28 females and 12 males) were randomly assigned to two groups. Group one were given 300 mg (3×100 mg capsules) standardized extract of ginseng, while group 2 took placebos. After eight weeks, anthropometric indices, glycosylated hemoglobin (HbA1c), interleukin 6 (IL6), tumor necrosis factor (TNFα) and high sensitive C- Reactive Protein (hsCRP) were studied. Results: In the present study, no significant differences were observed in anthropometric indices, glycated hemoglobin and TNFα in the intervention and placebo groups before and after intervention. At the end of the study, a significant reduction was observed in IL6 (8.43± 1.17 vs. 6.79±1.39 ng/L) and hsCRP (3.61±0.49 vs. 3.03±0.33 mg/dL) in the treatment group. Furthermore, there was a significant difference in IL6 (6.79±1.39 vs. 7.85±0.69 ng/L) and hsCRP (3.03±0.33 vs. 3.49±0.39 mg/dL) between the intervention and placebo groups at the end of the study. Conclusions: Administration of standardized ginseng extract for eight weeks caused reductions in IL6 and hsCRP in patients with type 2 diabetes. Therefore, administration of standardized extract of ginseng may play an effective role in the management of these patients.
Zahra Baji, Dr Fereshteh Zamani Alavijeh, Sedighe Nouhjah, Mohammad Hossein Haghighizadeh,
Volume 16, Issue 6 (3-2015)
Abstract
Introduction: To prevent diabetes
complications and improve the quality of life of these patients, adherence to
self-care is essential. The purpose of present study was to examine self-care
behaviors and related factors in women with type 2 diabetes. Materials and
Methods: This descriptive analytic cross sectional study was performed on
140 female patients with type 2 diabetes who referred to the diabetes clinic in
Ahvaz between December-March 2014. Research data were collected through
interviews using demographic and disease characteristics questionnnaires and the
summary of diabetes self-care activities measure. Validity and reliability of
the questionnaire was assessed and approved. The range of self-care scale was
0-77. Data were analyzed using descriptive statistics, Pearson's correlation
coefficients tests, t-test, one-way ANOVA, Kruskal-Wallis and multiple linear
regression models. Results: The mean score of self-care behaviors in
patients was 11.55±30.93, indicating moderate self-care. The highest mean scores
were those of diet, 16.28±5.38 and proper medication compliance 5.74±2.57,
while blood sugar monitoring 1.89±3.38 and physical activity 2.24±3.09 showed
the lowest scores. The score of self-care behaviors showed a statistically significant
difference among levels of education, duration of disease, life network, level
of fasting blood glucose and mode of physician referral (P<0.05). These significant
variables, except fasting blood glucose explained 23% of self-care variance. Conclusion:
The findings of this study could be useful for designing and implementation of
educational programs to promote self-care behaviors and more effective control
of type 2 diabetes in women.
Sm Asadi Ferizi, Dr K Hejazi, Dr Vr Askari, Ah Haghighi,
Volume 24, Issue 3 (9-2022)
Abstract
Introduction: Paraquat triggers oxidative stress and apoptosis. This study aimed to explore the effects of 7-week aerobic training and piperine supplementation on oxidative stress markers of brain tissue in male Wistar rats exposed to paraquat. Materials and Methods: Forty-eight adult rats were divided into 6 groups: 1) sham, 2) paraquat (negative control), 3) paraquat+training, 4) paraquat+training+piperine, 5) paraquat+piperine, and 6) paraquat+vitamin E. Aerobic training included 7 weeks of walking on a treadmill, 5 sessions per week for 30-40 minutes per session with 10 to 18 m/min. The paraquat was prepared at a dose of 5 mg/kg body weight; it was injected intraperitoneally 3 times a week. The animals were fed daily on piperine supplementation (20 mg) and vitamin E (20 mg/kg body weight). Oxidative stress markers, including malondialdehyde (MDA) and glutathione (GSH) levels, were measured in samples obtained from the brain hippocampus tissue. Results: The MDA concentration was significantly higher in the negative control group (2.20±0.24) than in the sham (0.54±0.16), paraquat + training (1.64±0.25), paraquat+piperine (1.57±0.24), paraquat+training+piperine (1.16±0.18), and paraquat+vitamin E groups (1.43±0.15; P<0.001). However, the GSH concentration was significantly lower in the negative control group (1.63±0.20; P<0.001) than in sham (3.59±0.65), paraquat+training (1.94±0.25), paraquat+piperine (2.28±0.34), paraquat+training+piperine (3.20±0.39), and paraquat+vitamin E groups (2.08±0.31). Conclusion: The use of training alone and training with piperine supplementation can be considered a new strategy to prevent paraquat-induced neurotoxicity.
Dr H Haghighinejad , Dr N Pouralimohamadi , Dr H Mahdaviazad,
Volume 24, Issue 6 (3-2023)
Abstract
Introduction: Hypothyroidism is a common, important endocrine disorder. In this study, we aimed to evaluate family physicians' knowledge about hypothyroidism. Materials and Methods: This analytical cross-sectional study assessed the knowledge knowledge of hypothyroidismin 180 family physicians working in two Shiraz urban health centers in 2021. A researcher-made questionnaire containing four areas, including screening, diagnosis, treatment, and referral, was used. The total score of the questionnaire was 22. Initially, the validity and reliability of the questionnaire were confirmed in a pilot study. Results: 150 out of 180 participants completed the questionnaire. The average score was 15.7±2 of the total 22 scores. The mean scores on screening, diagnosis, treatment, and referral subscales were 0.8±3.2, 0.8±2.3, 1.4±6.6, and 0.6±3.5, respectively. Less than 50% of the doctors answered five out of 22 questions correctly. The doctor's age had a significant negative relationship with the questionnaire score. Conclusion: Although family physicians' knowledge was acceptable in screening, diagnosis, and referral areas, their knowledge of treatment was not sufficient. Using evidence-based national clinical guidelines and updating them at specific intervals, focusing on the performance of family physicians, can be an effective way to improve the knowledge and performance of these doctors. Planning for targeted retraining is suggested as another way to improve performance.
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