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Showing 7 results for mohebbi

Dr. H. Mohebbi, D M Moghadasi, Dr. F Rahmani-Nia, Dr. S. Hassan-Nia, Dr. H Noroozi,
Volume 12, Issue 1 (5-2010)
Abstract

Introduction: Central obesity down regulates adiponectin gene expression and plasma adiponectin concentration. The effects of lifestyle activity modification (LAM) training according to Centers for Disease Control (CDC) and American College of Sports Medicine ACSM guidelines on adiponectin gene expression and its secretion in obese people is not well known. The purpose of this study hence was to examine the effects of LAM on adiponectin gene expression and plasma adiponectin in obese men. Materials and Methods: Sixteen healthy middle aged men (42.06±6.01 years mean ± SD) participated in this study. The subjects were randomly assigned to the LAM (n=8) and control group (n=8). Subjects in the LAM group walked 2 miles for 30 minutes for 4 days for 12 weeks on treadmill according to the CDC and ACSM guidelines. After 12 weeks LAM training, subjects were asked to avoid any high intensity physical activity for a week. Results: The results showed that weight, BMI, body fat mass, body fat percent, central (visceral and subcutaneous) and peripheral subcutaneous fat volume, waist and hip circumstance and waist to hip ratio (WHR) were decreased significantly after 12 weeks in the LAM group, compared to the controls (P<0.05). After one week detraining, body composition in the training group was maintained and did not change significantly. Also, maximum oxygen uptake, adiponectin gene expression on abdominal and hip subcutaneous adipose tissue were increased significantly in the LAM group compared to controls after 12 weeks (P<0.05). On the other hand, after 12 weeks LAM training no significant differentces were observed in plasma adiponectin and serum high sensitive C reactive protein (hs-CRP), levels  between groups, while after one week detraining plasma adiponectin and serum hs-CRP levels were significantly increased and decreased respectively (P<0.05). Conclusion: Although, twelve weeks LAM training improved body composition, cardiorespiratory fitness and adiponectine gene expression in obese men, but the intensity and time of these exercises are not enough to increase plasma adiponectin and hs-CRP reduction.


Mehrzad Moghadasi, Hamid Mohebbi, Mohadeseh Alsadat Nematollah Zadeh Mahani,
Volume 13, Issue 5 (1-2012)
Abstract

Abstract Introduction: Exercise significantly prevents the progression of atherosclerosis and oxidized LDL-C (ox-LDL-C), facilitates monocyte-related atherogenesis. The effects of Lifestyle Activity Modification (LAM) training based on guidelines of the Centers for Disease Control (CDC) and the American College of Sports Medicine (ACSM) on serum oxidized LDL-C (ox-LDL-C) in obese people are not well known. We investigated the effect of LAM on serum ox-LDL-C in obese middle aged men. Materials and Methods: Sixteen healthy obese middle aged men (aged 42.06±6.01 years, mean ± SD) were randomly assigned to the LAM (n=8) and the control (n=8) groups. Subjects in the LAM group walked 2 miles daily in 30 minutes 4 days weekly for 12 weeks on treadmills, according to the CDC and ACSM guidelines. Results: Results showed that body weight, BMI, body fat mass, body fat percent, waist to hip ratio (WHR) and LDL-C decreased significantly after 12 weeks in the LAM group compared to the controls (P<0.05), and their maximum oxygen uptake was increased significantly compared to the controls after 12 weeks (P<0.05). On the other hand, after 12 weeks of LAM training, no significant differences were observed in serum ox-LDL-C, total cholesterol (TC), triglycerides (TG) and HDL-C between the groups. Conclusion: Although twelve weeks of LAM improved body composition and cardio-respiratory fitness and decreased LDL-C levels in obese middle aged men, serum ox-LDL-C were not affected by this protocol in this group.
Elham Fayaz, Hamid Mohebbi, Arsalan Damirchi,
Volume 13, Issue 6 (9-2011)
Abstract

Introduction: The purpose of this research was to determine level of physical activity, calcium intake, calcium sources and anthropometrical variables in young college females. According to the information obtained using a physical activity questionnaire, the subjects were divided to 3 groups (active, hypoactive, inactive). Materials and Methods: In this cross-sectional study 160 young females (aged 20/51±1/4 yrs mean + SD) participated. Levels of physical activity and calcium intake were determined by a questionnaire and body composition was determined using the Bioelectrical ImPedance (BIA) method. Results: Results indicated that only 22/5% of subjects were active and that calcium intake of female students was less than the recommended daily allowance (RDA). There was a significant association between physical activity and all anthropometrical variables except for BMI. There was also a significant relationship between calcium intake and with lean body mass (P=0/024, r= 0/17), calcium from dairy sources with lean body mass (P=0/022, r= 0/18) and calcium from cereal sources with body fat percent (P=0/026, r= -0/17). There was significant difference in lean body mass, body fat percentage and fat distribution in the groups regarding levels of physical activity (P<0/05). Lean body mass in the active group was significantly higher than in the active group but fat percentage and fat distribution was less than the hypoactive and inactive groups (P<0/05). Conclusion: The results of this study indicate although the active group compared to the hypoactive and inactive groups had good physiological, anthropometrical and nutritional status, it unfortunately constitutes a low percentage of individuals and hence the level of physical activity, nutritional patterns and lifestyles of female students should be monitored.
Dr Hamid Mohebbi, Hadi Rohani, Dr Sadegh Hassan-Nia, Dr Nazanin Pirooznia,
Volume 15, Issue 3 (10-2013)
Abstract

Abstract

Introduction: The purpose of this study was evaluating the effect of obesity and weight reduction induced by endurance training on UCP3 mRNA expression in C57BL/6 mice. Materials and Methods: Twenty-four C57BL/6 mice consumed a high-fat diet, while 6 (NB Group) were fed a normal chow for 12 weeks. After the fattening period, 6 obese mice (OB Group) were sacrificed. Twelve mice trained 5 sessions per week for 12 weeks on a rodent treadmill with high (HI Group) (~75% VO2max) and/or low intensity (LI Group) (~50% VO2max) during a training period. The control group (OC Group) was kept inactive in the cages till the end of the period. Body weight was measured and recorded weekly. UCP3 mRNA expression was measured in gastrocnemius muscle using Real Time-PCR method and plasma FFA concentrations were measured using the ELISA method. Results: In the training groups, weight reduction was significant in the 8th week (p<0.05). Average relative UCP3 mRNA expression was significantly lower in the HI and LI groups, than in the OC group (0.5±0.25 and 1.04±0.96, respectively, vs. 2.58±0.57 arbitrary unit p<0.05). Plasma FFA conce­ntrations were significantly lower in the HI and OB groups compared to the LI group (p<0.05). Conclusion: When energy intake and consequently body weight increases, UCP3 increases to extend the thermogenesis and fatty acid oxidation’s process. In contrast, UCP3 downregulates with exercise-induced weight loss in order to counteract this process.


Payam Saidie, Dr Hamid Mohebbi, Dr Farhad Rahmaninia, Dr Fahime Mohammad Ghasemi,
Volume 17, Issue 4 (12-2015)
Abstract

Introduction: The aim of present study was to investigate the interaction of aerobic training and calorie restriction on levels of adiponectin isomers in serum and abdominal fat depots in obese male rats. Materials and Methods: Forty-eight wistar male rats were used as the study sample. Blood and tissue samples were collected at the 1st, 18th and 28th weeks. After baseline sampling, the remaining 40 rats were randomly divided into control and high-fat-diet groups. The high-fat-diet group received their regimen for 18 weeks and were then randomly divided into the negative energy balance (NEB) and high-fat-diet (HFD) subgroups. NEB group alternately underwent 25% calorie restriction or aerobic training (running) with an intensity of 70 to 75% of vo2max for 10 weeks. Results: Compared to the standard diet, HFD feeding increased weight and decreased retroperitoneal adipose tissue adiponectin level at the 18th and 28th weeks (P<0.05). In comparison to the HFD, group negative energy balance in obese male rats, caused weight control with significant increase in serum levels of total and high-molecular-weight adiponectin as well as adiponectin levels in retroperitoneal and mesenteric fat depots (P<0.05). Also insulin resistance index in line with serum concentrations of insulin, glucose and triglycerides were decreased in negative energy balance, compared to the high-fat-diet group (P<0.05). Conclusion: This study indicates that even with simultaneous consumption of high-fat-diet, combination of aerobic training and calorie restriction can increase concentrations of adiponectin in serum and abdominal fat depots of obese male rats, and aligned with it improves lipid and metabolic profiles.


Mousa Khalafi, Dr Hamid Mohebbi, Dr Pouran Karimi,
Volume 20, Issue 3 (10-2018)
Abstract

Introduction: The purpose of this study was to investigate the effects of high intensity interval training (HIIT) and moderate intensity continuous training (MICT) on irisin, FGF-21 and insulin resistance in obese male rats. Material and Methods: Forty male rats were divided into two groups: high-fat diet (n=32) and standard diet (n=8), for 10 weeks. After inducing obesity, eight rats from the high-fat diet group (O) and eight  from the standard dietary group (C) were sacrificed, and the other obese rats were randomly divided into three groups: obesity control (OC), moderate intensity continuous training (MICT) and high intensity interval training (HIIT). The HIIT protocol, including 10 bouts of 4-minute activity with equivalent intensity of 85-90% vo2max and 2 minute active rest periods, and the MICT protocol with equivalent intensity of 65-70% VO2max, with covered distance matched to that of the HIIT protocol, were performed for 12 weeks and 5 sessions per week. Serum samples were collected in two steps (after completion of diet and training protocols) to measure serum levels of irisin, FGF-21, insulin and glucose by ELISA. Results: In the comparison of the HIIT group to the OC group, serum levels of irisin (6.43 ±0.93 ng/ml vs. 4.61±0.61 ng/ml, p=0.003) and FGF-21 (1658±206.5 ng/l vs. 1093±125.97 ng/l, P=0.007) significantly increased, while MICT had no significant effect on these two hormones (P=0.29, P=1.00 respectively). Also, when comparing both the HIIT and MICT groups to the OC group, serum levels of glucose (HIIT: 111.16±4.07 mg/dl, MICT: 117.5±1.37 mg/dl vs. 154.66±13.21 mg/dl, P=0.001, P=0.001 respectively) and insulin resistance index (HIIT: 1.96±0.20, MICT: 2.53±0.46 vs. 3.89±0.54, P=0.001, P=0.01 respectively) significantly decreased; although, serum insulin reduction (1.49±0.15 ng/ml vs. 2.14±0.43 ng/ml, P=0.018) was only significant in the HIIT group (P=0.018). Conclusion: It seems that both HIIT and MICT training protocols lead to improved insulin resistance in obese rats. However the increase in serum irisin and FGF-21 was significant only in the HIIT group, suggesting that exercise intensity plays an important role in regulating the secretion of these hormones.
 

Dr S Bonakdaran, Dr M Esmaeilzadeh, Dr M Mohebbi, Dr Z Mazloum Khorasani, Dr Z Mousavi, Dr M Yaghoubi,
Volume 23, Issue 5 (12-2021)
Abstract

Introduction: Studies examining the effect of Empagliflozin in patients with type 2 diabetes have reported different results regarding the effect of this drug on electrolytes and lipid profiles. This study aimed to evaluate the effect of Empagliflozin on electrolytes and lipid profiles in patients with type 2 diabetes. Materials and Methods: In this systematic meta-analysis, clinical trials published in the Web of Science, Scopus, PubMed, and Cochrane Library databases up to April 2022 were reviewed. Information on the mean and standard deviations of electrolytes, including phosphate, calcium, sodium, potassium, magnesium, and lipid parameters, including total cholesterol, low-density lipoprotein (LDL), high-density lipoprotein (HDL), and triglycerides, before receiving Empagliflozin was extracted from the selected studies and analyzed. Results: A total of seven clinical trials with 398 patients were analyzed. The sodium, potassium, phosphate, and magnesium levels remained unchanged or slightly changed after receiving different doses of Empagliflozin. Estimation of the standardized mean difference of calcium after receiving 10 mg of Empagliflozin was insignificant. The standardized mean difference in levels of total cholesterol, LDL cholesterol, HDL cholesterol, and triglycerides was insignificant after receiving different doses of Empa­gliflozin. Conclusion: Administration of Empagliflozin in patients with type 2 diabetes does not affect phosphate, calcium, sodium, potassium, magnesium, total cholesterol, LDL cholesterol, HDL cholesterol, and triglycerides. However, further research is needed due to the small number of studies and conflicting results on the issue.

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مجله ی غدد درون‌ریز و متابولیسم ایران، دو ماهنامه  پژوهشی مرکز تحقیقات غدد درون‌ریز و متابولیسم، Iranian Journal of Endocrinology and Metabolism
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