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Introduction: The incidence of permanent and transient CH has not yet been determined in Iran. This report illustrates the incidence of permanent and transient CH in Tehran and Damavand. Materials and Methods: From February 1998 to August 2002, cord dried blood spot samples in Tehran and Damavand were collected and those with TSH 20 mU/L were recalled (two-site IRMA). Between 7-14 days of life or thereafter, CH was confirmed by serum TSH >10 mU/L and T4 <6.5 g/dL or TSH >30 mU/L alone and L-T4 was immediately started. CH-affected newborns were followed-up until May 2003. Dysgenesis was determined using 99mTC thyroid scanning and /or ultrasonography. In thyroid eutopic newborns, dyshormonogenesis was diagnosed by a 4-week discontinuation of L-T4 between 2-3 years of age and abnormal serum TSH and T4 values, while normal levels after discontinuation confirmed transient CH. Cases with incomplete early follow-ups without thyroid imaging, were known as unknown CH. Results: Of 35067 screened neonates 373 had cord TSH 20 mU/L and were recalled (recall rate: 1.06%). 35 had CH (incidence of 1:1002 births), 25 had permanent CH (incidence of 1:1403 births), and 6 had transient CH (incidence of 1:5845 births). The type of CH remained unknown in 4 cases. Thyroid dysgenesis and dyshormonogenesis were detected in 18 (incidence of 1:1948 births) and 7 cases (incidence of 1:5010 births), respectively. Conclusions: The high incidence of permanent CH underlines the necessity to implement a national CH screening program in Iran.

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Introduction: Primary amenorrhea is one of the most important complaint of women in reproductive age. To determine the causes responsible for primary amenorrhea this study was performed on the basis of clinical, sonography and laboratories investigations. Material and Method: This case series study was performed at Ayat –allah Taleghani teaching hospital during the years of 2003-5 . Data were collected from the patients who attended or referred to the clinics of gynecology or endocrinology wards since 10 years ago. Result: 53 cases were evaluated.Mean age of the patients was 26.82±7.24 years when they were visited at the clinics. The most common cause of primary infertility was mullerian dysgenesis (n=19) according to clinical, sonography and laboratories investigations. Hypogonadotropic hypogonadism and congenital adrenal hyperplasia were seen in 12 and 8 patients, respectively. 5 patients had gonadal dysgenesis. Conclusion: This study suggest that registration of patients with primary amenorrhea in research center, can be beneficial for diagnosis and intervention.