[Home ] [Archive]   [ فارسی ]  
:: Main :: About :: Current Issue :: Archive :: Search :: Contact ::
:: Volume 11, Issue 6 (4-2009) ::
2009, 11(6): 713-720 Back to browse issues page
Effects of Aging Associated with Weight Gain on The Cell Size and Heterogeneity of Different Fat Depots in The Rat
A. Ghorbani Dr. , M Varedi Dr., GR Ranjbar Omrani Dr.
, ghorbani_ahmad@yahoo.com
Abstract:   (23489 Views)

Abstract

Introduction: The mass of adipose tissue expands during weight gain mostly because of an increase in fat cell diameter, which is one of the most important determinants of tissue metabolism. The aim of this study was to examine the effects of aging associated with weight gain on cell size and heterogeneity of adipocytes at different fat depots. Materials and Methods: Adipose tissues were harvested from subcutaneous (SC), retroperitoneal (RP), perirenal (PR), proximal epididymal (PE) and distal epididymal (DE) regions of two groups of rats with a 30-day difference in age and 36% increase in body weight. Diameters of fat cells were measured using a microscope equipped with a calibrated micrometer. Cell size heterogeneity was deduced from coefficient of variation. Results: In both groups, no significant regional differences were observed in diameter of adipocytes in various fat depots. With the exception of the RP depot, the weight gain caused a significant increase in diameter of adipocytes in all other depots. The highest and the lowest increase were seen in PR and RP adipocyte diameter, respectively. The degree of heterogeneity of fat depots was not significantly altered by weight gain. Conclusion: Aging associated with weight gain leads to fat cell hypertrophy in a depot specific manner, and cells at depots close to survival organs such as kidney and gonads are more affected than those of the other depots. The results of this study can enhance current knowledge on adipose tissue mass expansion and its related health complications such as cardiovascular diseases and diabetes.

Keywords: Adipose tissue, Cell diameter, Weight gain, Aging, Rat
Full-Text [PDF 346 kb]   (1602 Downloads)    
Type of Study: Original |
Received: 2010/04/8
Add your comments about this article
Your username or Email:

CAPTCHA code


XML   Persian Abstract   Print


Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Ghorbani A, Varedi M, Ranjbar Omrani G. Effects of Aging Associated with Weight Gain on The Cell Size and Heterogeneity of Different Fat Depots in The Rat . Iranian Journal of Endocrinology and Metabolism. 2009; 11 (6) :713-720
URL: http://ijem.sbmu.ac.ir/article-1-930-en.html


Volume 11, Issue 6 (4-2009) Back to browse issues page
مجله ی غدد درون‌ریز و متابولیسم ایران، دو ماهنامه  پژوهشی مرکز تحقیقات غدد درون‌ریز و متابولیسم، Iranian Journal of Endocrinology and Metabolism
Persian site map - English site map - Created in 0.06 seconds with 32 queries by YEKTAWEB 3855