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:: Volume 11, Issue 3 (9-2009) ::
2009, 11(3): 245-250 Back to browse issues page
The Effect of Alpha-Lipoic Acid on Blood Pressure in Type 2 Diabetics
Z. Mazloom , H. Ansar
, zohremazlom@yahoo.co.in
Abstract:   (13438 Views)

Abstract

Introduction: Majority of diabetic patients eventually develop hypertension. Becase of its antioxidative properties, alpha-lipoic acid plays an effective role in decreasing oxidative stress and preventing endothelium dysfunction. The purpose of the present study was to determine the effect of alpha-lipoic acid on blood pressure in type 2 diabetic patients. Materials & Methods: Fifty-seven type 2 diabetic patients (14 male and 43 female), mean age 53.5 years, were enrolled in this study. Upon arrival subjects were randomly divided into either the experimental (n=29) or control (n=28) groups. The experimental group received 300 mg alpha-lipoic acid daily for eight weeks, while the control group received a placebo for eight weeks. Blood pressure and 24 hours diet recall were measured at the beginning of the study and every two weeks after that. Results: The results of the study showed a significant decrease in both systolic and diastolic blood pressures at the end of study in the alpha lipoic acid group compared to their initial values (p<0/0001), and to the control group (p=0/001). Conclusion: This study suggests that alpha-lipoic acid supplements can be recommended for type 2 diabetic patients to prevent high blood pressure.

Keywords: Alpha-lipoic acid, Type 2 diabetes, Blood pressure, Oxidative stress, Antioxidant
Full-Text [PDF 264 kb]   (3427 Downloads)    
Type of Study: Original |
Received: 2009/10/25
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Mazloom Z, Ansar H. The Effect of Alpha-Lipoic Acid on Blood Pressure in Type 2 Diabetics. Iranian Journal of Endocrinology and Metabolism. 2009; 11 (3) :245-250
URL: http://ijem.sbmu.ac.ir/article-1-806-en.html


Volume 11, Issue 3 (9-2009) Back to browse issues page
مجله ی غدد درون‌ریز و متابولیسم ایران، دو ماهنامه  پژوهشی مرکز تحقیقات غدد درون‌ریز و متابولیسم، Iranian Journal of Endocrinology and Metabolism
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