:: Volume 10, Issue 5 (1-2009) ::
2009, 10(5): 527-532 Back to browse issues page
The Effect of Thiazolidenedione on Glucocorticoid Induced Central Obesity in Rats
M Soveid, MR Kalantarhormozi, Z Azizi, Gh Ranjbar Omrani
, msoveid@sums.ac.ir
Abstract:   (33090 Views)


Introduction: Central obesity is a common complication of glucocorticoids which is associated with insulin resistance. In some studies, thiazolidinediones have decreased central obesity in type 2 diabetic patients. The purpose of this study was to investigate the effect of pioglitazone on glucocorticoid induced central obesity in rats. Materials and Methods: Forty Sprague-Daily rats were divided into 2 groups, with 10 male and 10 female rats in each. In group 1, methylprednisolone succinate 5 mg/kg was injected 3 times per week and pioglitazone 30 mg/kg/day was given. In group 2, only methylprednisolone succinate was administered. After 3 weeks, the rats were sacrificed and visceral fat was removed, and the weight of visceral fat, abdomen circumference and total body weight in the 2 groups were compared. Results: The weight of animals was not different significantly however animals given pioglitazone had less visceral fat (7.32±2.60 vs 11.95± 2.76 gr P<0.001) and lower abdominal circumference (11.92±1.20 vs 14.98±1.74 cm P<0.001). Conclusion: Pioglitazone has antagonistic effect on glucocorticoid induced central obesity.

Keywords: Pioglitazone, Glucocorticoid, Central obesity, Thiazolidinedione
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Type of Study: Original |
Received: 2009/02/5 | Published: 2009/01/15

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Volume 10, Issue 5 (1-2009) Back to browse issues page