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:: Volume 13, Issue 2 (8-2011) ::
2011, 13(2): 209-220 Back to browse issues page
Genetic Association Between Metabolic Syndrome and Apolipoproteins
Shahla Shojaei, Maryam alsadat Daneshpour Dr, Sohrab Halalkhor, Fereidoun Azizi Dr , Mehdi Hedayati Dr
, hedayati@endocrine.ac.ir
Abstract:   (38045 Views)

Introduction: Metabolic syndrome, a collection of risk factors for cardiovascular risk factors, refers to a cluster of symptoms, the simultaneous occurrence of which in a person is more likely than the occurrence of each perse.  The criteria proposed by the International Diabetes Federation for the diagnosis of this syndrome include central obesity, increased triglycerides, decreased HDL-C, hypertension, and increased fasting blood sugar. Signs of metabolic syndrome can be determined through the interconnected physical and chemical changes in the human body, genetic and environmental factors. One of the most effective factors in metabolic syndrome is change in the lipid profiles. Based on the roles of apolipoproteins in lipid metabolism, the possibility of their role in metabolic syndrome has been documented. The aim of this review is to evaluate the genetic roles of apolipoproteins in metabolic syndrome. Overall, the evidence suggests that the apolipoproteins A particularly APOA5 more associated with this syndrome. On the other hand, despite the prominent role of apolipoprotein B in fat metabolism, there is no evidence on any correlation between B-100 apolipoprotein and lipoproteins such as HDL and triglyceride levels of the symptoms of metabolic syndrome.

Keywords: Apolipoprotein, Metabolic Syndrome, Gene
Full-Text [PDF 346 kb]   (3067 Downloads)    
Type of Study: Review | Subject: Cardiology
Received: 2008/12/22
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shojaei S, Daneshpour M A, Halalkhor S, Azizi F, Hedayati M. Genetic Association Between Metabolic Syndrome and Apolipoproteins. Iranian Journal of Endocrinology and Metabolism. 2011; 13 (2) :209-220
URL: http://ijem.sbmu.ac.ir/article-1-598-en.html

Volume 13, Issue 2 (8-2011) Back to browse issues page
مجله ی غدد درون‌ریز و متابولیسم ایران، دو ماهنامه  پژوهشی مرکز تحقیقات غدد درون‌ریز و متابولیسم، Iranian Journal of Endocrinology and Metabolism
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