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:: Volume 10, Issue 1 (5-2008) ::
2008, 10(1): 67-74 Back to browse issues page
Protective Effect of Vitamin E on Diabetes Induced Apoptosis and Oxidative Stress in Rat Heart Tissue
A. Shiroo , S. Salami , M. Khadem Ansari , F. Ghaderi Pakdel , K. Khadem Vatani , R. Saadatian , M. Karimipour
, ashirpoor@yahoo.com
Abstract:   (25801 Views)
Abstract Introduction: The purpose of this study was to determine and to assess the protective effect of vitamin E on cardiomyocyte apoptosis and oxidative stress status in the heart under hyperglycemic conditions, in vivo. Materias and Methods: Wistar male rats (n=16) at 6 months of age were made hyperglycemic by STZ. Same age, normal wistar rats (n=8) were used for comparison (controls). Diabetic rats were divided into two groups, the nontreated and those treated with vitamin E (300mg/kg/daily). Results: Diabetic rats exhibited severe apoptosis in cardiomyocytes. Also significant increases in lipid peroxidation as measured by 8- isoprostan, protein oxidation as measured by protein carbonyl content and superoxide dismutase were observed after 6 weeks. Catalase activity was shown to increase in controls compared to nontreated rats. A distinct elevation in the HbA1C, QT interval and a decline in the activity of catalase were also observed. Vitamin E treated rats shown significant decline in apoptosis, lipid peroxidation, protein carbonyl and QT interval compared to nontreated rats. Conclusion: Vitamin E decreased the incidence of apoptosis in cardiomyocytes, lipid peroxidation and improve antioxidant enzyme in the diabetic hearts of rats. Further research to confirm the findings is recommended.
Keywords: Diabetes, Vitamin E, Wistar rat, Cardiomyocyte, Apoptosis, Oxidative stress
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Type of Study: Original | Subject: Endocrinology
Received: 2008/06/23
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Shiroo A, Salami S, Khadem Ansari M, Ghaderi Pakdel F, Khadem Vatani K, Saadatian R et al . Protective Effect of Vitamin E on Diabetes Induced Apoptosis and Oxidative Stress in Rat Heart Tissue. Iranian Journal of Endocrinology and Metabolism. 2008; 10 (1) :67-74
URL: http://ijem.sbmu.ac.ir/article-1-496-en.html


Volume 10, Issue 1 (5-2008) Back to browse issues page
مجله ی غدد درون‌ریز و متابولیسم ایران، دو ماهنامه  پژوهشی مرکز تحقیقات غدد درون‌ریز و متابولیسم، Iranian Journal of Endocrinology and Metabolism
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