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:: Volume 9, Issue 1 (Junne 2007 2007) ::
2007, 9(1): 85-90 Back to browse issues page
Association of Apolipoprotein E gene polymorphism and obesity in an Iranian population: Tehran Lipid and Glucose study
M. Hedayati PhD , F. Hosseinpanah PhD, F. Sarvghadi PhD, M. Tohidi PhD, M. Daneshpour, P. Eshraghi, F. Azizi PhD
, hedayati@erc.ac.ir
Abstract:   (27264 Views)
Abstract Introduction: The Apo E is one of the genes, which play a role in the regulation of lipid metabolism, especially in obesity. In other studies a common Apo E polymorphism has been shown to be associated with obesity, and in the present study our aim is to determine this association in an Iranian population. Materials & Methods: Subjects were randomly selected from the Tehran Lipid and Glucose Study and classified into 3 in three groups according to their body mass index: BMI<25, 25BMI<30, BMI30 and finally 429(150 in men and 179 in women). We measured FBS, HDL-C, triglyceride, cholesterol levels and blood pressure for all individuals. A segment of the mentioned gene with PCR was amplified and the polymorphism with RFLP (HhaI) revealed. Results: The allele frequency of Apo E polymorphism was in the Hardy Weinberg equilibrium and the allele frequency was e2 (0.065), e3 (0.851) and e4 (0.083) there was no relation between BMI and the frequency of this allele. Conclusion: These results show that there is no relation between Apo E polymorphism and BMI in this study.
Keywords: Obesity, Apo E, BMI, Polymorphism
Full-Text [PDF 268 kb]   (2918 Downloads)    
Type of Study: Original | Subject: Endocrinology
Received: 2007/10/10
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Hedayati M, Hosseinpanah F, Sarvghadi F, Tohidi M, Daneshpour M, Eshraghi P et al . Association of Apolipoprotein E gene polymorphism and obesity in an Iranian population: Tehran Lipid and Glucose study. Iranian Journal of Endocrinology and Metabolism. 2007; 9 (1) :85-90
URL: http://ijem.sbmu.ac.ir/article-1-384-en.html


Volume 9, Issue 1 (Junne 2007 2007) Back to browse issues page
مجله ی غدد درون‌ریز و متابولیسم ایران، دو ماهنامه  پژوهشی مرکز تحقیقات غدد درون‌ریز و متابولیسم، Iranian Journal of Endocrinology and Metabolism
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