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:: Volume 8, Issue 3 (12-2006) ::
2006, 8(3): 275-279 Back to browse issues page
Frequency of macroprolactinemia in hyperprolactinemic patients with simple polyethylene glycol precipitation test
N Tayebi Meybodi , M Farzadniya , S Amuyan , B Memar , A Nejat Shokohi , F Heidari , SJ Abdolmomen Toosi
, naser_tayyebi@yahoo.com
Abstract:   (24864 Views)
Introduction: Hyperprolactinemia is seen not only in pregnancy but also in several pathological conditions, However, some patients with hyperprolactinemia are diagnosed as idiopathic, because the causes are unknown. They are subjected to repeated radiological examinations to find a microadenoma, to a long term treatment with bromocriptine, and even to a surgical intervention. There is evidence that macroprolactinemia, in which most circulating PRL form large protein complexes (>150 KDa), is a major cause of idiopathic hyperprolactinemia. Macroprolactinemic patients are clinically characterized by lack of or less hyperprolactinemia – related symptoms. The objective of this study was to assess the prevalence of macroprolactinemia in hyperprolactinemic patients. Materials and Methods: Prolactin was measured before and after precipitation of macroprolactin by polyethylene glycole in 113 hyperprolactinemic (PRL>28 µg/L patients. Results: In 23% of the patients, macroprolactinemia was found. Conclusion: Considering the high prevalence of macroprolactinemia and to avoid diagnostic and therapeutic pitfalls, the screening for macroprolactinemia in all hyperprolactinemic patients is recommended.
Keywords: Macroprolactin, Hyperprolactinemia, Prolactin, Polyethylene glycole
Full-Text [PDF 274 kb]   (2158 Downloads)    
Type of Study: Original | Subject: Endocrinology
Received: 2007/02/13
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Tayebi Meybodi N, Farzadniya M, Amuyan S, Memar B, Nejat Shokohi A, Heidari F et al . Frequency of macroprolactinemia in hyperprolactinemic patients with simple polyethylene glycol precipitation test. Iranian Journal of Endocrinology and Metabolism. 2006; 8 (3) :275-279
URL: http://ijem.sbmu.ac.ir/article-1-338-en.html


Volume 8, Issue 3 (12-2006) Back to browse issues page
مجله ی غدد درون‌ریز و متابولیسم ایران، دو ماهنامه  پژوهشی مرکز تحقیقات غدد درون‌ریز و متابولیسم، Iranian Journal of Endocrinology and Metabolism
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