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Impact of vitamin and/or mineral supplementation on lipid profiles in type 2 diabetes
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M Farvid   , F Siassi , M Jalali , M Hosseini , N Saadat |
| , farvidm@hotmail.com |
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Abstract: (36728 Views) |
| Introduction: The purpose of the present study was to assess the impact of Mg+Zn, vitamin C+E, and combination of these micronutrients on serum lipid and lipoprotein profiles in type 2 diabetic patients. Material and Methods: In a randomized, double blind, placebo controlled clinical trial, 69 type 2 diabetic patients under diet and hypoglycemic drugs were randomly divided into four groups. Each group received one of the following daily supplement for 3 months group M: 200 mg Mg and 30 mg Zn (n=16), group V: 200 mg vitamin C and 150 mg vitamin E (n=18), group MV: minerals plus vitamins (n=17), group P: placebo (n=18). Results: Results indicate that after 3 months of supplementation mean serum levels of HDL-c and apolipoprotein A1 increased significantly in the MV group by 24% (50.4±19.3 vs. 40.6±10.8 mg/dL) and 9% (170±34 vs. 156±24 mg/dL), respectively (p<0.01). There were no significant changes in the levels of these parameters in the other 3 groups. Serum levels of total cholesterol, LDL-c, triglyceride, and apolipoprotein B were not altered after supplementation in all 4 groups. Conclusion: It is concluded that since co-supplementation of Mg, Zn, vitamin C and E significantly increases HDL-c and apolipoprotein A1, supplementation of these micronutrients should be recommended for type 2 diabetic patients based on their daily requirements. |
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| Keywords: Type 2 diabetes, Vitamin C, Vitamin E, Magnesium, Zinc, Lipid, HDL-c, Apolipoproteins |
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Full-Text [PDF 380 kb]
(3084 Downloads)
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Type of Study: Original |
Subject:
Endocrinology
Received: 2007/02/7 | Published: 2004/06/15
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