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Non-coding RNAs in Brown Adipose Tissue and Thermogenesis
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Fatemeh Kazeminasab    , Leila Fathtabar |
| Department of Physical Education and Sport Sciences, Faculty of Human Sciences, University of Kashan, Kashan, Iran , f_kazemi85@yahoo.com |
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Abstract: (1827 Views) |
| Obesity is caused by excessive accumulation of subcutaneous and visceral white adipose tissue and an imbalance between energy intake and consumption. Because the prevalence of obesity is increasing worldwide, prevention methods have become particularly important. In new anti-obesity strategies, in addition to limiting energy intake and increasing its consumption, energy dissipation in the form of heat or thermogenesis is considered. Because thermogenesis occurs primarily in brown adipose tissue (BAT), identifying BAT provides an opportunity to design an anti-obesity drug intervention by increasing energy expenditure and thermogenesis. Understanding the molecular and cellular pathways and regulatory factors, including non-coding RNAs involved in the thermogenesis process in BAT, is a crucial strategy for therapeutic applications against obesity and obesity-related diseases. Non-coding RNAs, including miRNAs and lncRNAs, are essential regulators in biological processes. Besides, miRNAs are a group of small non-coding RNAs with vital regulatory roles in regulating gene expression. Recent studies have also shown that BAT-specific non-coding RNAs play a key role in regulating the function of brown adipogenesis, browning of white adipose tissue (such as beige adipogenesis), and brown thermogenesis. In this study, miRNAs and lncRNAs related to genes involved in brown adipose tissue and thermogenesis were investigated. These miRNAs and lncRNAs may be used in the future as biomarkers and therapeutic targets for the prevention and treatment of obesity and obesity-related diseases. |
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| Keywords: Non-coding RNAs, miRNA, lncRNA, Brown adipose tissue, Thermogenesis |
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Full-Text [PDF 2539 kb]
(586 Downloads)
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Type of Study: Review |
Subject:
Physiology
Received: 2021/07/25 | Accepted: 2021/10/16 | Published: 2021/04/30
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