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The effect of vitamin C supplements on glycated hemoglobin in type 2 diabetic patients
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B Forghani   , V Gohariyan , N Kassaian , M Amini |
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Abstract: (34991 Views) |
| Abstract: Glycated hemoglobin (HbA1C) is known as an indicator of diabetes metabolic control and glycation of proteins. There are some evidences about the role of vitamin C on inhibition of hemoglobin glycation. So, in this study, we evaluated the effect of vitamin C on glycated hemoglobin (HbA1C) level in type 2 diabetic patients. A clinical trial study was conducted on 18 type 2 diabetic patients (14 women, 4 men). We used 1000 mg supplement of vitamin C (4250 mg) per day for 6 weeks. BMI, 3-day food records, fasting plasma glucose and glycated hemoglobin were measured before and after using vitamin C supplements. The results were analyzed by paired t-test and P<0.05 was considered significant. Glycated hemoglobin was significantly decreased at the end of the study (P<0.015). Fasting plasma sugar increased slightly but it was not statistically significant. Our results show that vitamin C, which has structural similarities with glucose, can reduce the glycosylation of hemoglobin in type 2 diabetic patients through competition with glucose. This effect can be used to control the pathogenic mechanism of protein glycation in diabetes, after more detailed studies. |
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| Keywords: Diabetes mellitus; Vitamin C; Fasting blood sugar; Glycosylated hemoglobin; Body mass index |
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Type of Study: Original |
Subject:
Endocrinology
Received: 2006/11/30 | Published: 2000/12/15
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