[Home ] [Archive]   [ فارسی ]  
:: Main :: About :: Current Issue :: Archive :: Search :: Contact ::
:: Volume 22, Issue 1 (10-2020) ::
2020, 22(1): 83-91 Back to browse issues page
Comparison of the Effects of Combined Oral Contraceptives Containing Progestins with Low Androgenic and Anti-androgenic Activities on the Clinical, Androgenic, and Metabolic Manifestations of Polycystic Ovary Syndrome
Mina Amiri Dr. , Fahimeh Ramezani Tehrani Dr.
Shahid Beheshti University of Medical Sciences , ramezani@endocrine.ac.ir
Abstract:   (232 Views)
Introduction: Combined oral contraceptives (COCs) are commonly considered as the first-line treatment for polycystic ovary syndrome (PCOS). This study aimed to compare the effects of COCs with respect to their progestin component on the clinical, hormonal, and metabolic outcomes of women with PCOS. Data were extracted by searching PubMed, Scopus, EMBASE, and Google Scholar, without any time limitations (until 2020). All studies assessing the effects of COCs on PCOS patients of childbearing age were reviewed and discussed. Based on the findings, different types of COCs can improve hyperandrogenism and regulate the menstrual cycle by suppressing gonadotropins and increasing sex hormone-binding globulin. Compared to COCs containing androgenic progestins (e.g., desogestrel and levonorgestrel), COCs containing anti-androgenic progestins (e.g., cyproterone acetate and drospirenone) could reduce androgen deprivation through specific mechanisms. However, the available evidence does not support the superiority of these anti-androgenic compounds in improving the clinical manifestations of hyperandrogenism. While all COCs may be associated with lipid disorders, drospirenone-containing compounds seem to be associated with the fewest disorders. Also, as COCs may result in metabolic disorders, especially dyslipidemia, it is necessary to periodically measure metabolic parameters in COC-consuming patients.
Keywords: Combined oral contraceptives (COCs), Progestin, Polycystic ovary syndrome (PCOS)
Full-Text [PDF 1088 kb]   (55 Downloads)    
Type of Study: Review | Subject: Endocrinology
Received: 2020/04/8 | Accepted: 2020/07/29 | Published: 2020/10/1
Add your comments about this article
Your username or Email:

CAPTCHA


XML   Persian Abstract   Print


Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Amiri M, Ramezani Tehrani F. Comparison of the Effects of Combined Oral Contraceptives Containing Progestins with Low Androgenic and Anti-androgenic Activities on the Clinical, Androgenic, and Metabolic Manifestations of Polycystic Ovary Syndrome. Iranian Journal of Endocrinology and Metabolism. 2020; 22 (1) :83-91
URL: http://ijem.sbmu.ac.ir/article-1-2717-en.html


Volume 22, Issue 1 (10-2020) Back to browse issues page
مجله ی غدد درون‌ریز و متابولیسم ایران، دو ماهنامه  پژوهشی مرکز تحقیقات غدد درون‌ریز و متابولیسم، Iranian Journal of Endocrinology and Metabolism
Persian site map - English site map - Created in 0.05 seconds with 31 queries by YEKTAWEB 4237