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:: Volume 20, Issue 6 (3-2019) ::
2019, 20(6): 344-355 Back to browse issues page
The Effects of Neonatal Exposure of Formononetin Drived from Red Clover on Some Parameters of Sexually Dimorphic of Mice
Rahmatollah Parandin Dr , Leili Mohhamadi
Payame Noor University , rahmatparandin@pnu.ac.ir
Abstract:   (1732 Views)

Introduction: Formononetin is a phytostrogen found in plants such as red clover (Trifolium pratense), which has a chemical structure similar to the estradiol hormone. The aim of this study was to investigate the effects of formononetin derived from red clover on sexual dimorphic indices in mice during neonatal life. Materials and Methods: In this experimental study, male and female neonate mice were randomly divided into the control, vehicle and 3 groups (n=8) received formonetonin subcutaneously at doses of 5, 50 and 500 mg/kg body weight on days 1-5 after birth. After examining the puberty timing, parameters of estrus cycle, anogenital distance, sexual behavior, preferred saccharin and sex hormones were also investigated. The data were analyzed by SPSS statistical software and OneWay ANOVA test. Significance was shown at p values<0.05. Results: Puberty in females was significantly advanced by 500 mg/kg (p<0.01) and in male mice was delayed by 50 (p<0.05) and 500 mg/kg formonotonin (p<0.01). Mean duration of estrus cycle increased in 500 mg/kg formonotonin (p<0.05). Lordosis and mount numbers in 500 (p<0.001) decreased and the mean latency to the first mounts increased by 500 formonotonin (p<0.001). Percentage of saccharin preference increased by 50 (p<0.05) and 500 mg/kg formonotonin (p<0.01) in female mice. In addition, estradiol level in 50 (p<0.01) and 500 mg/kg (p<0.001) doces decreased and testosterone level in 500 formonotonin mg/kg (p<0.01) decreased, compared with controls. Conclusion: The results of this study show that the administration of formonotonin during the neonatal period of mice has the potential to cause development of sexual dimorphism parameters.

Keywords: Formonotonin, sexually dimorphic, estrogen, mice
Full-Text [PDF 1405 kb]   (343 Downloads)    
Type of Study: Original | Subject: Physiology
Received: 2018/09/25 | Accepted: 2019/03/12 | Published: 2019/03/15
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Parandin R, Mohhamadi L. The Effects of Neonatal Exposure of Formononetin Drived from Red Clover on Some Parameters of Sexually Dimorphic of Mice. Iranian Journal of Endocrinology and Metabolism. 2019; 20 (6) :344-355
URL: http://ijem.sbmu.ac.ir/article-1-2470-en.html

Volume 20, Issue 6 (3-2019) Back to browse issues page
مجله ی غدد درون‌ریز و متابولیسم ایران، دو ماهنامه  پژوهشی مرکز تحقیقات غدد درون‌ریز و متابولیسم، Iranian Journal of Endocrinology and Metabolism
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