[Home ] [Archive]   [ فارسی ]  
:: Main :: About :: Current Issue :: Archive :: Search :: Contact ::
:: Volume 5, Issue 1 (3-2003) ::
2003, 5(1): 45-51 Back to browse issues page
Changes in calcium, vitamin D, and other biochemical factors during pregnancy
E Ainy , A Mirsaeed Ghazi, P Mirmiran, M Mirbolooki, F Azizi
Abstract:   (25000 Views)
Introduction: Calcium and vitamin D play major roles in calcium homeostasis and skeletal development, especially during pregnancy. This study was conducted to determine serum constituents related to calcium metabolism of pregnant women as compared to non-pregnant ones. Material and Methods: In a cross sectional study, 48 pregnant women from 5 prenatal care centers, and 66 non-pregnant women randomly selected from the Tehran Lipid and Glucose Study population were enrolled in the study. A questionnaire was used to obtain demographic information for both groups. Venous blood samples were taken to measure serum calcium, phosphorus, magnesium, alkaline phosphatase, albumin, parathyroid hormones, 25-OH vitamin D and serum osteocalcin levels. The repeated measure procedure and Dunnett test were used for statistical analysis. Data were adjusted for age in both case and control groups. Results: Significant differences were found in the mean serum levels of albumin, osteocalcin and alkaline phosphatase between three trimesters of pregnancy (P<0.001). These differences were also significant in comparison to the control group. The mean values of albumin were 4.8±0.3, 4.3±0.3, 4.4±0.4, and 5.0±2 in the first, second and third trimesters and the control group respectively. These values for osteocalcin were 12.7±8.5, 8.1±6.7, 5.6±5.0 and 15.3±9.4 respectively and those for alkaline phosphatase were 115±38, 125±37, 174±61 and 137±42 respectively. In the first trimester alkaline phosphatase and 25-OH vitamin D decreased and albumin, parathyroid hormone and osteocalcin increased. In the first trimester 20% and 40% had vitamin D<10 ng/ml and <20 ng/ml respectively. Conclusion: Significant changes in albumin, parathyroid hormone, osteocalcin and alkaline phosphatase are observed in pregnant women throughout pregnancy. Vitamin D decreases in the first trimester and 20% have vitamin D deficiency.
Keywords: Calcium metabolism, Pregnancy, Vitamin D, Osteocalcin, Bone, Parathyroid hormone.
Full-Text [PDF 318 kb]   (4683 Downloads)    
Type of Study: Original | Subject: Endocrinology
Received: 2006/11/23 | Published: 2003/03/15
Add your comments about this article
Your username or Email:


XML   Persian Abstract   Print

Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Ainy E, Mirsaeed Ghazi A, Mirmiran P, Mirbolooki M, Azizi F. Changes in calcium, vitamin D, and other biochemical factors during pregnancy. Iranian Journal of Endocrinology and Metabolism. 2003; 5 (1) :45-51
URL: http://ijem.sbmu.ac.ir/article-1-232-en.html

Volume 5, Issue 1 (3-2003) Back to browse issues page
مجله ی غدد درون‌ریز و متابولیسم ایران، دو ماهنامه  پژوهشی مرکز تحقیقات غدد درون‌ریز و متابولیسم، Iranian Journal of Endocrinology and Metabolism
Persian site map - English site map - Created in 0.05 seconds with 31 queries by YEKTAWEB 4218