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:: Editorial Board
:: About Iranian Journal of Endocrinology and Metabolism
:: Volume 20, Issue 1 (7-2018) ::
2018, 20(1): 38-49 Back to browse issues page
New Strategies for Production and Designing of Cytokines and Hormones Antagonists, Focusing on Leptin and Growth Hormone
Fatemeh Elmi , Hamid Zarkesh-Esfahani , Setareh Paghouhnia , Abass Soleimani , Niloofar Sasani , Roya Daneshazari
Isfahan university- faculty of science , s.h.zarkesh@sheffield.ac.uk
Abstract:   (7997 Views)

Introduction: Antagonist is a chemical substance or drug that has the ability to bind to the cell receptor by the ligand-receptor process, but is not able to trigger a response. Antagonists, pharmacologically, mimic the action of an agonist on the cell. It prevents, however, the attachment and function of the agonist or allows the binding but not the appropriate function by blocking the binding site of the agonist on the cell surface. In the past, antagonist production required much  experimentation, trial and error whereas today, with advances in science and identification of molecular structure and signaling techniques, the possibilities of intelligent designs for antagonists in the shortest time possible have arisen. This process is based on two general viewpoints that include: Drug design based on target that can be a receptor or based on the structure of a small molecule as a drug that can block the signaling. The basic structure of an antagonist changes during drug design and hence there could be an antagonist with high levels of activity and minimal side effects. This review studied the new strategies of designing antagonists for cytokines and hormones (focusing on leptin and growth hormone). Since hormones play multiple roles in different physiological conditions and cytokines act as immune modulators, designing antagonists for them or their receptors can play an important role in the treatment of autoimmune-inflammatory-and neoplastic diseases.

Keywords: Antagonist, Design strategy, Cytokine, Hormone
Full-Text [PDF 533 kb]   (1125 Downloads)    
Type of Study: Review | Subject: General
Received: 2017/09/27 | Accepted: 2018/03/17 | Published: 2018/07/15
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Elmi F, Zarkesh-Esfahani H, Paghouhnia S, Soleimani A, Sasani N, Daneshazari R. New Strategies for Production and Designing of Cytokines and Hormones Antagonists, Focusing on Leptin and Growth Hormone. Iranian Journal of Endocrinology and Metabolism 2018; 20 (1) :38-49
URL: http://ijem.sbmu.ac.ir/article-1-2319-en.html

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Volume 20, Issue 1 (7-2018) Back to browse issues page
مجله ی غدد درون‌ریز و متابولیسم ایران، دو ماهنامه  پژوهشی مرکز تحقیقات غدد درون‌ریز و متابولیسم، Iranian Journal of Endocrinology and Metabolism
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