:: Volume 19, Issue 3 (9-2017) ::
2017, 19(3): 170-176 Back to browse issues page
Effects of High Intensity Interval Training and Moderate-Intensity Continuous Training on VEGF Gene Expression in Visceral and Subcutaneous Adipose Tissues of Male Wistar Rats
Sara Ghafari Homadini , Mohammad Reza Asad , Behzad Bazgir , Mostafa Rahimi
, Mostafa.rahimi20@gmail.com
Abstract:   (8125 Views)

Introduction: The purpose of present study was to investigate the effects of high intensity interval training (HIIT) and moderate-intensity continuous training (MICT) on vascular endothelial growth factor (VEGF) gene expression in visceral and subcutaneous adipose tissues in male Wistar rats. Materials and Methods: For this experimental study, 24 male Wistar rats (250±20 gram) were divided in to 4 groups (n=6 each) basal control (n=6), 8 week controls (n=6), MICT (n=6), and HIIT (n=6) groups. The training program was running on the 4 treadmill for 8 weeks/5 days per week. Intensity of the MICT protocol was 50-75% of VO2max, and the duration was approxinately 15 to 60 minutes, which progressively increased. The HIIT protocol was 4-8×1 min with 70-100% of VO2 max and 1 min recovery with 50-70% VO2max, for a total duration of 15 to 23 minutes. Adipose tissue samples were removed 48 hours after the last training session and VEGF gene expression was measured by Real-Time PCR methods. Results: Results indicated that both MICT and HIIT induced significant increase in subcutaneous VEGF gene expression (P≤0.05), whereas, no significant changes in visceral VEGF gene expression were observed after either training protocol (P≥0.05). Conclusion: Based on findings, the MICT protocol, HIIT exercise training in particular, has more effects on subcutaneous adipose tissue angiogenesis than on visceral adipose tissue. 

Keywords: Adipose tissue, Angiogenesis, Moderate-intensity continuous training, High intensity interval training, Vascular endothelial growth factor
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Type of Study: Original | Subject: Exercise
Received: 2017/05/24 | Accepted: 2017/08/6 | Published: 2017/09/20

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Volume 19, Issue 3 (9-2017) Back to browse issues page